6-Aminouracil

Modify Date: 2024-01-02 19:21:16

6-Aminouracil Structure
6-Aminouracil structure
Common Name 6-Aminouracil
CAS Number 873-83-6 Molecular Weight 127.101
Density 1.7±0.1 g/cm3 Boiling Point 580.4±53.0 °C at 760 mmHg
Molecular Formula C4H5N3O2 Melting Point ≥360 °C(lit.)
MSDS Chinese USA Flash Point 304.8±30.9 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name 6-Aminouracil
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 580.4±53.0 °C at 760 mmHg
Melting Point ≥360 °C(lit.)
Molecular Formula C4H5N3O2
Molecular Weight 127.101
Flash Point 304.8±30.9 °C
Exact Mass 127.038177
PSA 91.74000
LogP -2.33
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.746
Water Solubility slightly soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YQ8750000
CHEMICAL NAME :
Uracil, 6-amino-
CAS REGISTRY NUMBER :
873-83-6
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C4-H5-N3-O2
MOLECULAR WEIGHT :
127.12
WISWESSER LINE NOTATION :
T6MVMVJ FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Parenteral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2400 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CBCCT* "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. (National Academy of Science Library, 2101 Constitution Ave., NW, Washington, DC 20418) Volume(issue)/page/year: 7,696,1955

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Safety Phrases S22-S24/25
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS YQ8750000
HS Code 29335995

 Synthetic Route

~95%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Sariri; Khalili Russian Journal of Organic Chemistry, 2002 , vol. 38, # 7 p. 1053 - 1055

~%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: DE117922 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 6, p. 1189 Chemische Berichte, , vol. 33, p. 1381,3044 Chem. Zentralbl., , vol. 72, # I p. 547

~49%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Katori; Nagano; Kunieda; Hirobe Chemical and pharmaceutical bulletin, 1981 , vol. 29, # 10 p. 3075 - 3077

~%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: DE170657 ; Fortschr. Teerfarbenfabr. Verw. Industriezweige, vol. 8, p. 1142

~12%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Journal of Heterocyclic Chemistry, , vol. 27, # 4 p. 1079 - 1083

~%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Nucleosides, Nucleotides and Nucleic Acids, , vol. 27, # 8 p. 967 - 978

~%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Journal of Organic Chemistry, , vol. 16, p. 1879,1881,1887

~12%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Journal of Heterocyclic Chemistry, , vol. 27, # 4 p. 1079 - 1083

~%

6-Aminouracil Structure

6-Aminouracil

CAS#:873-83-6

Literature: Bioorganic and Medicinal Chemistry, , vol. 21, # 22 p. 6868 - 6877

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles10

More Articles
Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Mini Rev. Med. Chem. 5(12) , 1113-23, (2005)

Thymidine Phosphorylase (TPase) catalyses the reversible phosphorolysis of pyrimidine 2'-deoxynucleosides to 2-deoxyribose-1-phosphate and their respective pyrimidine bases, including the phosphorolys...

Synthesis of 6-aminouracils and pyrrolo[2,3-d]pyrimidine-2,4-diones and their inhibitory effect on thymidine phosphorylase.

Nucleic Acids Symp. Ser. (37) , 59-60, (1997)

Inhibitors of thymidine phosphorylase (dThdPase) are expected to suppress the growth and metastasis of tumor cells by inhibition of angiogenesis and were designed by utilizing the three dimensional st...

Synthesis, chemical and pharmacological properties of some 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido [4,5-d]pyrimidines.

Acta Pol. Pharm. 53(1) , 39-46, (1996)

Synthesis of 6-substituted 2,4-dioxo-1,2,3,4,5,6,7,8-octahydropyrimido[4,5-d]pyrimidines [III-VI] obtained by cyclocondensation of 1-phenyl-6-aminouracil with formaline and the primary amines is descr...

 Synonyms

4-Amino-2,6-dihydroxypyrimidine
6-Amino-2,4(1H,3H)-pyrimidinedione
2,4(1H,3H)-Pyrimidinedione, 6-amino-
4-AMINOURACI
6-amino-1H-pyrimidine-2,4-dione
MFCD00006071
6-aminopyrimidine-2,4-diol
Pyrimidine, 2,4-dihydroxy-6-amino
4-ADHP
EINECS 212-854-3
2,4-Dihydroxy-6-aminopyrimidine
AURORA KA-377
2,4-Dioxo-6-imino-1,3-diaza-hexahydrobenzol
6-aminopyrimidine-2,4(1H,3H)-dione
Barbitursaeure-4-imin
6-amino-1,2,3,4-tetrahydro-2,4-dioxopyrimidine
Imino-4-uracil
6-amino-5H-pyrimidine-2,4-dione
Aminouracil
2,6-Dioxo-4-imino-hexahydropyrimidin
6-Aminouracil
6-amino-1H,3H-pyrimidine-2,4-dione
4-AMINOURACIL
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