HEPES

Modify Date: 2024-01-02 13:04:49

HEPES structure	Common Name	HEPES
	CAS Number	7365-45-9	Molecular Weight	238.305
	Density	1.3±0.1 g/cm3	Boiling Point	N/A
	Molecular Formula	C₈H₁₈N₂O₄S	Melting Point	234-238 °C
	MSDS	Chinese USA	Flash Point	N/A

Use of HEPES

HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Name	2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Synonym	More Synonyms

Description	HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].
Related Catalog	Research Areas >> Others Signaling Pathways >> Others >> Others
References	[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828. [2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492. [3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Description

HEPES, a zwitterionic chemical buffering agent, is broadly applied in cell culture. HEPES is effective at pH 6.8 to 8.2. HEPES is a potent inducer of lysosome biogenesis[1][2][3].

Related Catalog

Research Areas >> Others

Signaling Pathways >> Others >> Others

References

[1]. Suzuki T, et al. Nonvolatile buffer coating of titanium to prevent its biological aging and for drug delivery. Biomaterials. 2010;31(18):4818-4828.

[2]. Sledź P, et al. An experimental charge density of HEPES. Acta Crystallogr B. 2010;66(Pt 4):482-492.

[3]. Tol MJ, et al. HEPES activates a MiT/TFE-dependent lysosomal-autophagic gene network in cultured cells: A call for caution. Autophagy. 2018;14(3):437-449.

Density	1.3±0.1 g/cm3
Melting Point	234-238 °C
Molecular Formula	C₈H₁₈N₂O₄S
Molecular Weight	238.305
Exact Mass	238.098724
PSA	89.46000
LogP	-2.67
Index of Refraction	1.543
Storage condition	2-8°C
Stability	Stable. Combustible. Incompatible with strong oxidizing agents. Protect from moisture.
Water Solubility	Soluble

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TL6809000

CHEMICAL NAME :: 1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

CAS REGISTRY NUMBER :: 7365-45-9

BEILSTEIN REFERENCE NO. :: 0883043

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C8-H18-N2-O4-S

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - quail

DOSE/DURATION :: >316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: EESADV Ecotoxicology and Environmental Safety. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1977- Volume(issue)/page/year: 6,149,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X9468 No. of Facilities: 239 (estimated) No. of Industries: 2 No. of Occupations: 7 No. of Employees: 3025 (estimated) No. of Female Employees: 2233 (estimated)

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S24/25-S22-S36-S26
RIDADR	NONH for all modes of transport
WGK Germany	1
RTECS	TL6809000
HS Code	29335995

HS Code	29335995

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4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid

hepesfreeacid

4-(2-Hydroxyethyl)piperazine-1-ethanesulfonic acid

HEPES.1/2Na

2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid

EIT hydrobromide

hepes solution

1-Piperazineethanesulfonic acid, 4-(2-hydroxyethyl)-

4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid

GOOD'S BUFFER

HEPES

HEPES BUFFER PH 8.0

2-[4-(2-Hydroxyethyl)-1-piperazinyl]ethanesulfonic acid

EINECS 230-907-9

HEPES,1M solution

MFCD00006158

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: HEPES
Price: ￥718.0/500g ￥218.0/100g
Purity: 98.0%
Stocking Period: Inquiry
Contact: Liu jia

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: HEPES
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: 4- (2-hydroxyerhyl) Piperazine-1-Erhaesulfonic Acid
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

Henan Tianfu Chemical Co., Ltd.
China
Product Name: 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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HEPES

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