Etilefrin

Modify Date: 2024-01-19 17:44:05

Etilefrin Structure
Etilefrin structure
Common Name Etilefrin
CAS Number 709-55-7 Molecular Weight 181.23200
Density 1.127 g/cm3 Boiling Point 351.7ºC at 760 mmHg
Molecular Formula C10H15NO2 Melting Point N/A
MSDS N/A Flash Point 155.5ºC

 Use of Etilefrin


Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3].

 Names

Name 3-[2-(Ethylamino)-1-hydroxyethyl]phenol
Synonym More Synonyms

 Etilefrin Biological Activity

Description Etilefrine (3-[2-(ethylamino)-1-hydroxyethyl]phenol) is an α adrenergic agonist[2]. Etilefrine also is an AMPK activator[1]. Etilefrine can be used for the research of postural hypotension[3].
Related Catalog
Target

AMPK

In Vivo Etilefrine (0.1 mg/kg; i.v.) increases blood pressure (BP) and heart rate (HR), however, Etilefrine does not attenuate the decrease in BP induced by the tilt. Etilefrine also tends to increase cardiac output (CO)[3].
References

[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24.

[2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5.

[3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

 Chemical & Physical Properties

Density 1.127 g/cm3
Boiling Point 351.7ºC at 760 mmHg
Molecular Formula C10H15NO2
Molecular Weight 181.23200
Flash Point 155.5ºC
Exact Mass 181.11000
PSA 52.49000
LogP 1.42600
Index of Refraction 1.561

 Safety Information

HS Code 2922509090

 Synthetic Route

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Etilefrin Structure

Etilefrin

CAS#:709-55-7

Literature: Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

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Etilefrin Structure

Etilefrin

CAS#:709-55-7

Literature: Yakugaku Zasshi, , vol. 74, p. 318 Chem.Abstr., , p. 3960

 Customs

HS Code 2922509090
Summary 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Synonyms

ethylphenylarsine chloride
Aethyl-chlor-phenyl-arsin
Arsine,chloroethylphenyl-(6CI,7CI,8CI)
Arsinous chloride,ethylphenyl
ethylphenylephrine
Aethyl-phenyl-dithiocarbamidsaeure,Ammonium-Salz
ethyl(phenyl)arsinous chloride
Aethylphenylarsinchlorid
Aethylphenylarsenchlorid
ethyl-chloro-phenyl-arsine
ammonium N-ethyl-N-phenyldithiocarbamate
Chloroethylphenylarsine
(RS)-etilefrine
2-ethylamino-1-(3-hydroxy-phenyl)-ethanol
ethyl-phenyl-dithiocarbamic acid,ammonium salt
Aethyl-phenyl-chlor-arsin
[3H]-(+/-)-Etilefrine
Ethylphenylchloroarsine