Cefmenoxime

Modify Date: 2024-01-06 20:36:10

Cefmenoxime structure	Common Name	Cefmenoxime
	CAS Number	65085-01-0	Molecular Weight	511.55800
	Density	1.96 g/cm3	Boiling Point	N/A
	Molecular Formula	C₁₆H₁₇N₉O₅S₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Cefmenoxime

Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2].

Name	cefmenoxime
Synonym	More Synonyms

Description	Cefmenoxime (SCE-1365) is a new semisynthetic cephalosporin antibiotic. Cefmenoxime has antibacterial activity against a wide variety of gram-positive and gram-negative bacteria[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Cefmenoxime (SCE-1365) inhibits at least 90% of strains tested (MIC90) ranged from 0.06 to 8 μg/mL for the Enterobacteriaceae[1]. Cefmenoxime (SCE-1365) inhibits MIC90 values for gram-positive cocci are 0.015 and ≤0.008 μg/mL for Streptococcus pneumoniae and Streptococcus pyogenes, respectively, and 2 μg/mL for S. aureus[1]. Cefmenoxime (SCE-1365) against Haemophilus influenzae, Neisseria gonorrhoeae and Neisseria meningitidis with MIC90 values ranging from ≤0.008 to 0.25 μg/mL[1].
In Vivo	Cefmenoxime (SCE-1365) (40 mg/kg; i.h.; daily, for 7 d; male Jcl:ICR mice) improves the survival rate of mice infected with lung bacteria[2]. Animal Model: Male Jcl:ICR mice[2] Dosage: 40 mg/kg Administration: Subcutaneous injection; daily, for 7 days Result: Inhibited mortality rate of animals was 60% at a dose of 40 mg/kg.
References	[1]. Stamm JM, et, al. Antimicrobial activity of cefmenoxime (SCE-1365). Antimicrob Agents Chemother. 1981 Mar;19(3):454-60. [2]. Tatara O, et, al. Synergistic effects of romurtide and cefmenoxime against experimental Klebsiella pneumonia in mice. Antimicrob Agents Chemother. 1992 Jan;36(1):167-71.

Density	1.96 g/cm3
Molecular Formula	C₁₆H₁₇N₉O₅S₃
Molecular Weight	511.55800
Exact Mass	511.05100
PSA	269.65000
LogP	0.04020

Hazard Codes	Xi
Risk Phrases	R41:Risk of serious damage to eyes.
Safety Phrases	S26-S39

Precursor 1
CAS#:24209-38-9 7-TMCA
DownStream 0

Cefmenoxime

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-,(6R,7R)

(6R,7R)-7-[[(Z)-(2-Aminothiazol-4-yl)(methoxyimino)acetyl]amino]-3-[[(1-methyl-1H-tetrazol-5-yl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid

SCE 1365

7-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido]-3-[[1-methyl-1H-tetrazol-5-yl]thiomethyl]-3-cephem-4-carboxylic acid

MFCD00864851

CMX