Foscarnet sodium

Modify Date: 2024-01-02 10:36:37

Foscarnet sodium structure	Common Name	Foscarnet sodium
	CAS Number	63585-09-1	Molecular Weight	191.951
	Density	N/A	Boiling Point	270-272°C
	Molecular Formula	CNa₃O₅P	Melting Point	62-65 °C(lit.)
	MSDS	N/A	Flash Point	270-272°C

Use of Foscarnet sodium

Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].

Name	trisodium phosphonoformate
Synonym	More Synonyms

Description	Foscarnet sodium (Trisodium phosphonoformate) is a viral DNA polymerase activity inhibitor, leading to reversible suppression of viral replication. Foscarnet sodium is an antiherpesvirus agent used in cytomegalovirus retinitis[1][2][3].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Cell Cycle/DNA Damage >> DNA/RNA Synthesis
In Vitro	Foscarnet sodium (Trisodium phosphonoformate) inhibits Influenza A Victoria (IC50=29 μM), Influenza B HK (IC50=61 μM), and Avian myeloblastosis virus (IC50=5-8 μM),HSV-1, several strains (IC50=0.4-3.5 μM)[2].
References	[1]. Manischewitz JF, et al. Synergistic effect of ganciclovir and foscarnet on cytomegalovirus replication in vitro.Antimicrob Agents Chemother. 1990 Feb;34(2):373-5. [2]. Oberg B, et al. Antiviral effects of phosphonoformate (PFA, foscarnet sodium).Pharmacol Ther. 1982;19(3):387-415. [3]. Hakki M, et al. Moving Past Ganciclovir and Foscarnet: Advances in CMV Therapy.Curr Hematol Malig Rep. 2020 Jan 24.

Boiling Point	270-272°C
Melting Point	62-65 °C(lit.)
Molecular Formula	CNa₃O₅P
Molecular Weight	191.951
Flash Point	270-272°C
Exact Mass	191.917648
PSA	113.13000
Storage condition	-20℃

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SY8200000

CHEMICAL NAME :: Phosphinecarboxylic acid, dihydroxy-, oxide, trisodium salt

CAS REGISTRY NUMBER :: 63585-09-1

LAST UPDATED :: 198910

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C-O5-P.3Na

MOLECULAR WEIGHT :: 191.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 2400 mg/kg/6D-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Kidney, Ureter, Bladder - changes in tubules (including acute renal failure, acute tubular necrosis)

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 2,216,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 384 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: USXXAM United States Patent Document. (U.S. Patent Office, Box 9, Washington, DC 20231) Volume(issue)/page/year: #4215113

Hazard Codes	Xi
Risk Phrases	R36/37/38:Irritating to eyes, respiratory system and skin .
Safety Phrases	S26-S36
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
Packaging Group	II
HS Code	2942000000

phenyl [ethoxy-...

CAS#:72304-84-8

~0%

Foscarnet sodium

CAS#:63585-09-1

[hydroxy-(4-met...

CAS#:74270-25-0

Literature: Noren; Helgstrand; Johansson; Misiorny; Stening Journal of Medicinal Chemistry, 1983 , vol. 26, # 2 p. 264 - 270

mono-(trimethyl...

CAS#:91076-68-5

Hexamethyldisilazane

CAS#:999-97-3

Foscarnet sodium

CAS#:63585-09-1

Literature: Phosphorus, Sulfur and Silicon and the Related Elements, , vol. 51/52, p. 778

Precursor 3
CAS#:72304-84-8 phenyl [ethoxy-... CAS#:91076-68-5 mono-(trimethyl... CAS#:999-97-3 Hexamethyldisilazane
DownStream 1
CAS#:1795-31-9 Tris(trimethyls...

HS Code	2942000000

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Foscarnet sodium

phosphoranecarboxylic acid, dihydroxy-, oxide, trisodium salt

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MFCD00013973

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SODIUM FOSCARNET

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FOSCARNET TRISODIUM SALT

phosphonoformate sodium salt

DC Chemicals Limited
China
Product Name: Foscarnet sodium
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Foscarnet sodium
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Zhejiang Hangyu API Co., Ltd
China
Product Name: Foscarnet sodium
Price: ￥Inquiry/1kg
Purity: 99.5%
Stocking Period: Inquiry
Contact: Vinnie

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