Decylubiquinone

Modify Date: 2024-01-02 19:50:27

Decylubiquinone Structure
Decylubiquinone structure
Common Name Decylubiquinone
CAS Number 55486-00-5 Molecular Weight 322.43900
Density 1.02g/cm3 Boiling Point 452.9ºC at 760 mmHg
Molecular Formula C19H30O4 Melting Point N/A
MSDS N/A Flash Point 196.2ºC

 Use of Decylubiquinone


Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].

 Names

Name 6-decylubiquinone
Synonym More Synonyms

 Decylubiquinone Biological Activity

Description Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].
Related Catalog
In Vitro Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced[1]. Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)[1]. Cell Viability Assay[1] Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells) Concentration: 10 μM Incubation Time: 6 hours Result: Attenuated the ROS increase in HL60 (B) cells.
References

[1]. Jeffrey S Armstrong, et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem. 2003 Dec 5;278(49):49079-84.

 Chemical & Physical Properties

Density 1.02g/cm3
Boiling Point 452.9ºC at 760 mmHg
Molecular Formula C19H30O4
Molecular Weight 322.43900
Flash Point 196.2ºC
Exact Mass 322.21400
PSA 52.60000
LogP 4.48990
Index of Refraction 1.487

 Safety Information

Hazard Codes Xi
Risk Phrases 36/37/38
Safety Phrases 26-36

 Precursor & DownStream

Precursor  0

DownStream  1

 Synonyms

2-decyl-5,6-dimethoxy-3-methyl-1,4-benzoquinone
decylubiquinone
2,3-dimethoxy-5-methyl-6-(n-decyl)-1,4-benzoquinone
2,3-Dmdb
2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione
decylbenzylquinone
MFCD00083306
6-Decylubiquinone
2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone
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