55486-00-5

55486-00-5 structure

Name: Decylubiquinone
Chemical Name: 6-decylubiquinone
CAS Number: 55486-00-5
Molecular Formula: C₁₉H₃₀O₄
Molecular Weight: 322.43900
Catalog: Research Areas Cancer
Create Date: 2018-11-23 22:58:53
Modify Date: 2024-01-02 19:50:27
Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].

Name	6-decylubiquinone
Synonyms	2-decyl-5,6-dimethoxy-3-methyl-1,4-benzoquinone decylubiquinone 2,3-dimethoxy-5-methyl-6-(n-decyl)-1,4-benzoquinone 2,3-Dmdb 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione decylbenzylquinone MFCD00083306 6-Decylubiquinone 2,3-Dimethoxy-5-methyl-6-decyl-1,4-benzoquinone

Description	Decylubiquinone is an analog of ubiquinone (coenzyme Q10). Decylubiquinone blocks reactive oxygen species (ROS) production in response to glutathione depletion and inhibits activation of the mitochondrial permeability transition[1].
Related Catalog	Research Areas >> Cancer Research Areas >> Neurological Disease
In Vitro	Decylubiquinone (dUb; 10 μm for 6 hours) exerts its effects on ROS by either inhibition of ROS production by cytochrome bc1 or that it scavenged ROS produced[1]. Decylubiquinone inhibits both the dichlorofluorescein (DCF) fluorescence increase resulting from H2O2 treatment and the DCF fluorescence increase resulting after glutathione (GSH) depletion using diethylmaleate mitochondrially generated ROS)[1]. Cell Viability Assay[1] Cell Line: HL60 cells transfected with bcl-2 (bcl-2) (HL60 B cells) Concentration: 10 μM Incubation Time: 6 hours Result: Attenuated the ROS increase in HL60 (B) cells.
References	[1]. Jeffrey S Armstrong, et al. The Coenzyme Q10 analog decylubiquinone inhibits the redox-activated mitochondrial permeability transition: role of mitcohondrial [correction mitochondrial] complex III. J Biol Chem. 2003 Dec 5;278(49):49079-84.

Precursor 0
DownStream 1
64845-31-4