Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide

Modify Date: 2024-02-28 20:13:28

Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide structure	Common Name	Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide
	CAS Number	5358-76-9	Molecular Weight	317.38
	Density	1.34g/cm3	Boiling Point	535.2ºC at 760mmHg
	Molecular Formula	C₂₀H₁₉N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	277.5ºC

Use of Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide

NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].

Name	2-piperidin-1-ylmethyl-indeno[1,2,3-de]quinazoline 1-oxide

Description	NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].
Related Catalog	Research Areas >> Others
References	[1]. Shin YJ, et al. Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells. Oncogene. 2015 Mar 5;34(10):1292-9. [2]. Li Q, et al. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul;39(29):5187-5200.

Description

Related Catalog

Research Areas >> Others

References

[1]. Shin YJ, et al. Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells. Oncogene. 2015 Mar 5;34(10):1292-9.

[2]. Li Q, et al. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul;39(29):5187-5200.

Density	1.34g/cm3
Boiling Point	535.2ºC at 760mmHg
Molecular Formula	C₂₀H₁₉N₃O
Molecular Weight	317.38
Flash Point	277.5ºC
Exact Mass	317.15300
PSA	41.59000
LogP	4.23450

DC Chemicals Limited
China
Product Name: NSC194598
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide

Use of Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide

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