5358-76-9

5358-76-9 structure

Name: Indeno[1,2,3-de]quinazoline, 2-(1-piperidinylmethyl)-, 1-oxide
Chemical Name: 2-piperidin-1-ylmethyl-indeno[1,2,3-de]quinazoline 1-oxide
CAS Number: 5358-76-9
Molecular Formula: C₂₀H₁₉N₃O
Molecular Weight: 317.38
Catalog: Research Areas Others
Create Date: 2016-05-25 00:01:04
Modify Date: 2024-02-28 20:13:28
NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].

Name	2-piperidin-1-ylmethyl-indeno[1,2,3-de]quinazoline 1-oxide

Description	NSC194598 is a p53 DNA-binding inhibitor with IC50 value of 180 nM and 2-40 μM for in vitro and in vivo, respectively. NSC194598 interferes with transcriptional activation of mutated RET gene in human medullary thyroid carcinoma TT cells. NSC194598 can be used for acute toxicity to normal tissues by radiation and chemotherapy research[1][2].
Related Catalog	Research Areas >> Others
References	[1]. Shin YJ, et al. Involvement of G-quadruplex structures in regulation of human RET gene expression by small molecules in human medullary thyroid carcinoma TT cells. Oncogene. 2015 Mar 5;34(10):1292-9. [2]. Li Q, et al. Inhibition of p53 DNA binding by a small molecule protects mice from radiation toxicity. Oncogene. 2020 Jul;39(29):5187-5200.