D-Ribonolactone

Modify Date: 2024-01-13 19:22:38

D-Ribonolactone Structure
D-Ribonolactone structure
Common Name D-Ribonolactone
CAS Number 5336-08-3 Molecular Weight 148.114
Density 1.7±0.1 g/cm3 Boiling Point 364.3±11.0 °C at 760 mmHg
Molecular Formula C5H8O5 Melting Point 83-85ºC
MSDS N/A Flash Point 162.8±12.8 °C

 Use of D-Ribonolactone


D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a Ki of 26 mM[1].

 Names

Name D-(+)-Ribonic Acid γ-Lactone
Synonym More Synonyms

 D-Ribonolactone Biological Activity

Description D-Ribonolactone is sugar lactone and an inhibitor of β-galactosidase of Escherichia coli with a Ki of 26 mM[1].
Related Catalog
Target

Human Endogenous Metabolite

In Vitro Ki: 26 mM (β-galactosidase)
References

[1]. Huber RE, et al. Strong inhibitory effect of furanoses and sugar lactones on beta-galactosidase Escherichia coli. Biochemistry. 1987 Mar 24;26(6):1526-31.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 364.3±11.0 °C at 760 mmHg
Melting Point 83-85ºC
Molecular Formula C5H8O5
Molecular Weight 148.114
Flash Point 162.8±12.8 °C
Exact Mass 148.037170
PSA 86.99000
LogP -2.47
Vapour Pressure 0.0±1.8 mmHg at 25°C
Index of Refraction 1.581

 Safety Information

Safety Phrases S22-S24/25
WGK Germany 3
HS Code 2932209090

 Synthetic Route

~66%

D-Ribonolactone Structure

D-Ribonolactone

CAS#:5336-08-3

Literature: BIOCRYST PHARMACEUTICALS, INC.; BABU, Yarlagadda, S.; KOTIAN, Pravin, L.; BANTIA, Shanta; WU, Minwan; KUMAR, V., Satish Patent: WO2014/78778 A2, 2014 ; Location in patent: Page/Page column 93 ;

~10%

D-Ribonolactone Structure

D-Ribonolactone

CAS#:5336-08-3

Literature: Isaac, Isabelle; Stasik, Imane; Beaupere, Daniel; Uzan, Raoul Tetrahedron Letters, 1995 , vol. 36, # 3 p. 383 - 386

~10%

D-Ribonolactone Structure

D-Ribonolactone

CAS#:5336-08-3

Literature: Procopio, Antonio; Gaspari, Marco; Nardi, Monica; Oliverio, Manuela; Tagarelli, Antonio; Sindona, Giovanni Tetrahedron Letters, 2007 , vol. 48, # 49 p. 8623 - 8627

~%

D-Ribonolactone Structure

D-Ribonolactone

CAS#:5336-08-3

Literature: Carbohydrate Research, , vol. 220, # 1 p. 117 - 126

~97%

D-Ribonolactone Structure

D-Ribonolactone

CAS#:5336-08-3

Literature: Pharmaceutical Chemistry Journal, , vol. 16, # 2 p. 135 - 139 Khimiko-Farmatsevticheskii Zhurnal, , vol. 16, # 2 p. 196 - 201

 Customs

HS Code 2932209090
Summary 2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Synonyms

D(+)-Ribonic acid gamma-lactone
D-Ribono-1,4-lactone
3,4-Dihydroxy-5-(hydroxymethyl)dihydro-2(3H)-furanone
3,4-dihydroxy-5-(hydroxymethyl)dihydrofuran-2(3H)-one (non-preferred name)
MFCD00063241
.γ.-Lactone of ribonic acid
D-(+)-Ribonic γ-lactone
EINECS 226-256-5
D-(+)-Ribono-1,4-lactone
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