(+)-Metamfetamine hydrochloride

Modify Date: 2024-01-02 13:46:06

(+)-Metamfetamine hydrochloride structure	Common Name	(+)-Metamfetamine hydrochloride
	CAS Number	51-57-0	Molecular Weight	185.694
	Density	N/A	Boiling Point	215.5ºC at 760mmHg
	Molecular Formula	C₁₀H₁₆ClN	Melting Point	166-168ºC
	MSDS	Chinese USA	Flash Point	86.8ºC
	Symbol	GHS06	Signal Word	Danger

Name	methamphetamine hydrochloride
Synonym	More Synonyms

Boiling Point	215.5ºC at 760mmHg
Melting Point	166-168ºC
Molecular Formula	C₁₀H₁₆ClN
Molecular Weight	185.694
Flash Point	86.8ºC
Exact Mass	185.097122
PSA	12.03000
LogP	3.02990

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SH5455000

CHEMICAL NAME :: Phenethylamine, N,alpha-dimethyl-, hydrochloride, (S)-(+)-

CAS REGISTRY NUMBER :: 51-57-0

LAST UPDATED :: 199706

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C10-H15-N.Cl-H

MOLECULAR WEIGHT :: 185.72

WISWESSER LINE NOTATION :: 1MY1R &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 10930 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 253,466,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 15 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,346,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 7560 ug/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 87,214,1946

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 6300 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02170

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 84,351,1954 ** TUMORIGENIC DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg female 1-21 day(s) after conception lactating female 19 day(s) post-birth

TOXIC EFFECTS :: Tumorigenic - neoplastic by RTECS criteria Reproductive - Tumorigenic effects - transplacental tumorigenesis

REFERENCE :: EAGRDS Experimental Aging Research. (Beech Hill Pub. Co., POB 136, Southwest Harbor, ME 04679) V.1- 1975- Volume(issue)/page/year: 5,509,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 792 mg/kg

SEX/DURATION :: male 4 week(s) pre-mating female 4 week(s) pre-mating - 3 week(s) post-birth

TOXIC EFFECTS :: Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: JONRA9 Journal of Neurochemistry. (Raven Press, 1185 Ave. of the Americas, New York, NY 10036) V.1- 1956- Volume(issue)/page/year: 20,625,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 80 mg/kg

SEX/DURATION :: female 13-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Specific Developmental Abnormalities - endocrine system Reproductive - Effects on Newborn - biochemical and metabolic

REFERENCE :: SYNAET Synapse. (Wiley-Liss, Inc., 605 Third Ave., New York, NY USA 10158-0012) V.1- 1987- Volume(issue)/page/year: 15,198,1993

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 17 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - musculoskeletal system

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 19 mg/kg

SEX/DURATION :: female 8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - other developmental abnormalities

REFERENCE :: NHOZAX Nippon Hoigaku Zasshi. Japanese Journal of Legal Medicine. (Nippon Hoi Gakkai, c/o Tokyo Daigaku Igakubu Hoigaku Kyoshitsu, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan) V.1- 1944- Volume(issue)/page/year: 46,126,1992 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X6179 No. of Facilities: 28 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 1579 (estimated) No. of Female Employees: 1099 (estimated)

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301
Precautionary Statements	P301 + P310
Personal Protective Equipment	Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges
Risk Phrases	25
RIDADR	UN 3249
RTECS	SH5455000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	2921499090

pseudoephedrine...

CAS#:345-78-8

~80%

(+)-Metamfetami...

CAS#:51-57-0

Literature: David, Gabrielle E.; Hibbert, D. Brynn; Frew, Russell D.; Hayman, Alan R. Australian Journal of Chemistry, 2010 , vol. 63, # 1 p. 22 - 29

L-(-)-Ephedrine

CAS#:299-42-3

~50%

(+)-Metamfetami...

CAS#:51-57-0

Literature: Matsumoto, Teruki; Urano, Yasuteru; Makino, Yukiko; Kikura-Hanajiri, Ruri; Kawahara, Nobuo; Goda, Yukihiro; Nagano, Tetsuo Analytical Chemistry, 2008 , vol. 80, # 4 p. 1176 - 1181

Sanedrine

CAS#:50-98-6

~63%

(+)-Metamfetami...

CAS#:51-57-0

Literature: Matsumoto, Teruki; Urano, Yasuteru; Makino, Yukiko; Kikura-Hanajiri, Ruri; Kawahara, Nobuo; Goda, Yukihiro; Nagano, Tetsuo Analytical Chemistry, 2008 , vol. 80, # 4 p. 1176 - 1181

D-Methamphetamine

CAS#:537-46-2

Benzyl chloride

CAS#:100-44-7

~0%

benzphetamine

CAS#:156-08-1

benzphetamine h...

CAS#:5411-22-3

Detail

Literature: MALLINCKRODT INC. Patent: WO2006/73547 A1, 2006 ; Location in patent: Page/Page column 7-8 ;

D-Methamphetamine

CAS#:537-46-2

Benzyl chloride

CAS#:100-44-7

~99%

benzphetamine

CAS#:156-08-1

(+)-Metamfetami...

CAS#:51-57-0

Literature: MALLINCKRODT INC. Patent: WO2006/73547 A1, 2006 ; Location in patent: Page/Page column 6-7 ;

BOC-pseudoephedrine

CAS#:152614-95-4

(+)-Metamfetami...

CAS#:51-57-0

Literature: Pramanik, Chinmoy; Bapat, Kiran; Chaudhari, Ashok; Kulkarni, Mukund G.; Kolla, Rangarao; Sompalli, Srinivasarao; Tripathy, Narendra K.; Gurjar, Mukund K. Organic Process Research and Development, 2014 , vol. 18, # 4 p. 495 - 500

Precursor 5
CAS#:345-78-8 pseudoephedrine... CAS#:299-42-3 L-(-)-Ephedrine CAS#:50-98-6 Sanedrine CAS#:537-46-2 D-Methamphetamine
CAS#:100-44-7 Benzyl chloride
DownStream 2
CAS#:6192-97-8 (2S)-1-cyclohex... CAS#:5411-22-3 benzphetamine h...

HS Code	2921499090
Summary	2921499090 other aromatic monoamines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Role of adenosine receptor subtypes in methamphetamine reward and reinforcement.

Neuropharmacology 89 , 265-73, (2014)

The neurobiology of methamphetamine (MA) remains largely unknown despite its high abuse liability. The present series of studies explored the role of adenosine receptors on MA reward and reinforcement...

Ibudilast reverses the decrease in the synaptic signaling protein phosphatidylethanolamine-binding protein 1 (PEBP1) produced by chronic methamphetamine intake in rats.

Drug Alcohol Depend. 152 , 15-23, (2015)

Chronic methamphetamine intake has been shown to induce a neuroinflammatory state leading to significant changes in brain functioning including behavioral changes. These changes can persist for years ...

Orexinergic neurotransmission in temperature responses to methamphetamine and stress: mathematical modeling as a data assimilation approach.

PLoS ONE 10 , e0126719, (2015)

Orexinergic neurotransmission is involved in mediating temperature responses to methamphetamine (Meth). In experiments in rats, SB-334867 (SB), an antagonist of orexin receptors (OX1R), at a dose of 1...

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Henan Tianfu Chemical Co., Ltd.
China
Product Name: (+)METHAMPHETAMINE HYDROCHLORIDE
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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(+)-Metamfetamine hydrochloride

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