β-Apopicropodophyllin
Modify Date: 2024-01-08 19:04:05
β-Apopicropodophyllin structure
|
Common Name | β-Apopicropodophyllin | ||
|---|---|---|---|---|
| CAS Number | 477-52-1 | Molecular Weight | 396.39000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H20O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of β-Apopicropodophyllinβ-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer[1]. |
| Name | (5R)-5-(3,4,5-trimethoxyphenyl)-8,9-dihydro-5H-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one |
|---|---|
| Synonym | More Synonyms |
| Description | β-Apopicropodophyllin is a nature product that could be isolated from Hyptis wticillata.β-Apopicropodophyllin induces apoptosis by inducing microtubule disruption, DNA damage, cell cycle arrest and ER stress. β-Apopicropodophyllin can be used in research of cancer[1]. |
|---|---|
| Related Catalog | |
| In Vitro | β-Apopicropodophyllin (0-100 nM; 48和72 h) 对 A549、NCI-H1299 和 NCI-460 细胞系具有抗癌活性，IC50 值分别为 16.9、13.1 和 17.1 nM [1]。 β-Apopicropodophyllin (0-20 nM; 24和48小时; A549, NCI-H1299 和 NCI-460细胞系) 破坏细胞内微管的聚合[1]。 β-Apopicropodophyllin (0-20 nM; 0-24 h; A549, NCI-H1299 和 NCI-460细胞株) 通过激活 ATM 诱导 DNA 损伤，将细胞周期阻滞在 G2/M 期，诱导内质网应激[1]。 β- apoopicropodophyllin (15 和 20 nM; 48小时; A549, NCI-H1299 和 NCI-460 细胞系) 诱导体外凋亡细胞死亡[1]。 Cell Viability Assay[1] Cell Line: A549, NCI-H1299 and NCI-460 cells Concentration: 0-100 nM Incubation Time: 48 and 72 hors Result: Inhibited cell growth in a dose-dependent manner. Apoptosis Analysis[1] Cell Line: A549, NCI-H1299 and NCI-460 cells Concentration: 15 and 20 nM Incubation Time: 48 h Result: Increased the percentage of apoptotic death in A549, NCI-H1299 and NCI-H460 cell groups in a time-dependent manner. Cell Cycle Analysis[1] Cell Line: A549, NCI-H1299 and NCI-460 cells Concentration: 0-20 nM Incubation Time: 8 and 16 h Result: Arrested cell cycle in G2/M phase. Western Blot Analysis[1] Cell Line: A549, NCI-H1299 and NCI-460 cells Concentration: 0-20 nM Incubation Time: 24 and 48 hors Result: Decreased the level of insoluble protein containing polymeric microtubules in a time-dependent manner in non-small cell lung cancer cell lines. Western Blot Analysis[1] Cell Line: A549, NCI-H1299 and NCI-460 cells Concentration: 0-20 nM Incubation Time: 24 h Result: Increased phosphorylated ATM and γ-H2AX levels in a dose-dependent manner. |
| In Vivo | β-Apopicropodophyllin (1 和 5 mg/kg; 瘤内注射; 异种移植裸鼠) 以剂量依赖性方式延缓肿瘤生长[1]。 Animal Model: nude mice with xenografts[1] Dosage: 1 and 5 mg/kg Administration: intra-tumorous injection Result: Inhibited tumor growth of NSCLC xenografts in nude mice. |
| References |
| Molecular Formula | C22H20O7 |
|---|---|
| Molecular Weight | 396.39000 |
| Exact Mass | 396.12100 |
| PSA | 72.45000 |
| LogP | 2.98250 |
| Vapour Pressure | 1.75E-13mmHg at 25°C |
| Precursor 0 | |
|---|---|
| DownStream 3 | |
CAS#:477-47-4
CAS#:518-28-5![5-(3,4,5-trimethoxyphenyl)-4,8,10,10a-tetrahydro-3aH-[2]benzofuro[5,6-f][1,3]benzodioxol-6-one structure](https://www.chemsrc.com/caspic/333/7461-03-2.png)
CAS#:7461-03-2| Furo(3',4':6,7)naphtho(2,3-d)-1,3-dioxol-6(8H)-one,5,9-dihydro-5-(3,4,5-trimethoxyphenyl)-,(R) |