AG-205
Modify Date: 2024-01-06 21:16:02
AG-205 structure
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Common Name | AG-205 | ||
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| CAS Number | 442656-02-2 | Molecular Weight | 454.97600 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H23ClN6OS | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
Use of AG-205(rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1]. |
| Name | 2-[1-(4-chlorophenyl)tetrazol-5-yl]sulfanyl-1-(2,8-dimethyl-3,4,4a,9b-tetrahydro-1H-pyrido[4,3-b]indol-5-yl)ethanone |
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| Synonym | More Synonyms |
| Description | (rac)-AG-205 is a potent inhibitor of progesterone receptor membrane component 1 (Pgrmc1) that induces genes involved in sterol synthesis, including the INSIG1 protein, which forms a complex with PGRMC1. (rac)-AG-205 prevents neuronal resistance to hypoxic ischaemia by blocking NF-kB signalling and activation of the BDNF/PI3K/AKT pathway[1]. |
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| Related Catalog | |
| References |
| Molecular Formula | C22H23ClN6OS |
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| Molecular Weight | 454.97600 |
| Exact Mass | 454.13400 |
| PSA | 92.45000 |
| LogP | 3.55360 |
| ag-205 |