methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside

Modify Date: 2024-01-10 23:44:49

methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside Structure
methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside structure
Common Name methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside
CAS Number 4330-34-1 Molecular Weight 384.42
Density 1.3±0.1 g/cm3 Boiling Point 581.4±50.0 °C at 760 mmHg
Molecular Formula C22H24O6 Melting Point N/A
MSDS N/A Flash Point 202.4±23.6 °C

 Use of methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside


Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].

 Names

Name 2-hydroxy-2-[(2R,3S)-3-hydroxy-5-methoxy-3-(2-methylbenzoyl)oxolan-2-yl]-1-(2-methylphenyl)ethanone
Synonym More Synonyms

  Biological Activity

Description Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc[1].
Related Catalog
References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88.  

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 581.4±50.0 °C at 760 mmHg
Molecular Formula C22H24O6
Molecular Weight 384.42
Flash Point 202.4±23.6 °C
Exact Mass 384.157288
PSA 93.06000
LogP 3.80
Vapour Pressure 0.0±1.7 mmHg at 25°C
Index of Refraction 1.607
Storage condition −20°C

 Safety Information

WGK Germany 3
HS Code 29389090

 Synthetic Route

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methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside Structure

methyl 2-deoxy-...

CAS#:4330-34-1

Literature: Koegler, Martin; Busson, Roger; De Jonghe, Steven; Rozenski, Jef; Van Belle, Kristien; Louat, Thierry; Munier-Lehmann, Helne; Herdewijn, Piet Chemistry and Biodiversity, 2012 , vol. 9, # 3 p. 536 - 556

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methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside Structure

methyl 2-deoxy-...

CAS#:4330-34-1

Literature: Dhimitruka, Ilirian; SantaLucia Jr., John Synlett, 2004 , # 2 p. 335 - 337

~%

methyl 2-deoxy-3,5-di-o-p-toluoyl-d-*rib ofuranoside Structure

methyl 2-deoxy-...

CAS#:4330-34-1

Literature: Rolland, Valerie; Kotera, Mitsuharu; Lhomme, Jean Synthetic Communications, 1997 , vol. 27, # 20 p. 3505 - 3511

 Synonyms

methyl 2-deoxy-3,5-di-O-p-toluoyl-D-ribofuranoside
1-o-methyl-2-deoxy-3,5-di(p-toluoyl)-erythro-pentafuranose
2-deoxy-1-O-methyl-3,5-di-O-p-toluoyl-D-ribofuranose
Methyl 2-Deoxy-3,5-di-O-p-toluoyl-D-erythro-pentoside
Methyl (5ξ)-2-deoxy-3-C-(2-methylbenzoyl)-6-(2-methylphenyl)-D-erythro-hexodialdo-1,4-furanoside
Methyl 2-deoxy-3,5-di-O-toluoyl-D-ribofuranoside
D-erythro-Hexodialdo-1,4-furanoside, methyl 2-deoxy-3-C-(2-methylbenzoyl)-6-(2-methylphenyl)-, (5ξ)-
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