21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

Modify Date: 2024-01-08 10:54:30

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione structure	Common Name	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione
	CAS Number	37413-91-5	Molecular Weight	366.450
	Density	1.2±0.1 g/cm3	Boiling Point	534.6±50.0 °C at 760 mmHg
	Molecular Formula	C₂₃H₂₆O₄	Melting Point	N/A
	MSDS	N/A	Flash Point	233.0±30.2 °C

Use of 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione

21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].

Name	[2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate
Synonym	More Synonyms

Description	21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione is an intermediate of delta 9,11 steroids synthesis, for example, Vamorolone (HY-109017). The delta 9,11 steroids are modifications of glucocorticoids and has anti-inflammatory properties. The delta 9,11 steroids are agents for protection against cell damage (lipid peroxidation) and inhibition of neovascularization[1].
Related Catalog	Research Areas >> Inflammation/Immunology Research Areas >> Metabolic Disease Signaling Pathways >> GPCR/G Protein >> Glucocorticoid Receptor
In Vitro	Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids[1]. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability[1].
References	[1]. Erica K M Reeves, et al. VBP15: preclinical characterization of a novel anti-inflammatory delta 9,11 steroid. Bioorg Med Chem

Density	1.2±0.1 g/cm3
Boiling Point	534.6±50.0 °C at 760 mmHg
Molecular Formula	C₂₃H₂₆O₄
Molecular Weight	366.450
Flash Point	233.0±30.2 °C
Exact Mass	366.183105
PSA	60.44000
LogP	3.48
Vapour Pressure	0.0±1.4 mmHg at 25°C
Index of Refraction	1.585