5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide

Modify Date: 2024-01-10 11:00:40

5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide Structure
5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide structure
Common Name 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide
CAS Number 355022-97-8 Molecular Weight 337.32900
Density N/A Boiling Point N/A
Molecular Formula C18H15N3O4 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide


Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].

 Names

Name 2-(5-Nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide

  Biological Activity

Description Anxiolytic/nonsedative agent-1 (compound 2b) is a potent and selective GABAA agonist. Anxiolytic/nonsedative agent-1 shows appreciable affinity for the BzR in bovine brain membranes with Kis of 14, 121, 239 nM for α1β2γ2, α2β2γ2, α5β3γ2, respectively. Anxiolytic/nonsedative agent-1 shows α2 selective efficacy in vitro and anxioselective effects in vivo[1].
Related Catalog
References

[1]. Taliani S, et al. Identification of anxiolytic/nonsedative agents among indol-3-ylglyoxylamides acting as functionally selective agonists at the gamma-aminobutyric acid-A (GABAA) alpha2 benzodiazepine receptor. J Med Chem. 2009 Jun 25;52(12):3723-34.

 Chemical & Physical Properties

Molecular Formula C18H15N3O4
Molecular Weight 337.32900
Exact Mass 337.10600
PSA 107.78000
LogP 4.05030