Silidianin

Modify Date: 2024-01-01 17:08:32

Silidianin structure	Common Name	Silidianin
	CAS Number	29782-68-1	Molecular Weight	482.436
	Density	1.7±0.1 g/cm3	Boiling Point	819.0±65.0 °C at 760 mmHg
	Molecular Formula	C₂₅H₂₂O₁₀	Melting Point	191 °C
	MSDS	Chinese USA	Flash Point	285.0±27.8 °C
	Symbol	GHS07	Signal Word	Warning

Use of Silidianin

Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].

Name	silydianin
Synonym	More Synonyms

Description	Silydianin is an active constituent of Silybium marianum, with exhibit anti-collagenase, antitumor and anti-elastase activities. Silydianin is a natural protein tyrosine phosphatase 1B (PTP1B) with an IC50 of 17.38 μM. Silydianin has inhibitory effect on the in vitro production and release of oxidative products[1][2][3].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase
References	[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6). [2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291. [3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.

Description

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Metabolic Enzyme/Protease >> Phosphatase

References

[1]. Vostálová J, et al. Skin Protective Activity of Silymarin and its Flavonolignans. Molecules. 2019 Mar 14;24(6).

[2]. Qin N, et al. Identification of flavonolignans from Silybum marianum seeds as allosteric protein tyrosine phosphatase 1B inhibitors. J Enzyme Inhib Med Chem. 2018 Dec;33(1):1283-1291.

[3]. Zielińska-Przyjemska M, et al. An in vitro study of the protective effect of the flavonoid silydianin against reactive oxygen species. Phytother Res. 2006 Feb;20(2):115-9.

Density	1.7±0.1 g/cm3
Boiling Point	819.0±65.0 °C at 760 mmHg
Melting Point	191 °C
Molecular Formula	C₂₅H₂₂O₁₀
Molecular Weight	482.436
Flash Point	285.0±27.8 °C
Exact Mass	482.121307
PSA	162.98000
LogP	1.84
Vapour Pressure	0.0±3.1 mmHg at 25°C
Index of Refraction	1.747
Storage condition	2-8°C

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302
Precautionary Statements	P301 + P312 + P330
Hazard Codes	Xn
Risk Phrases	22
Safety Phrases	22-45
RIDADR	NONH for all modes of transport
WGK Germany	3.0

Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes.

Pharmacol. Res. 25(2) , 147-54, (1992)

The effect of several flavanolignans (silicristin, silidianin, silybin and isosilybin) present in silymarin, the extract of Silybum marianum fruits, was tested on lipid peroxidation in rat liver micro...

[Silymarin in the treatment of chronic liver diseases: past and future].

Orv. Hetil. 149(51) , 2413-8, (2008)

In the treatment of chronic liver diseases adequate therapy can be chosen only in the knowledge of pathogenetic processes. In the liver diseases caused by oxidative stress (alcoholic and non-alcoholic...

Separation and characterization of silybin, isosilybin, silydianin and silychristin in milk thistle extract by liquid chromatography-electrospray tandem mass spectrometry.

J. Chromatogr. A. 1116(1-2) , 57-68, (2006)

A selective and sensitive liquid chromatography/tandem mass spectrometry (LC/MS/MS) method has been developed for the characterization of silymarin in commercially available milk thistle extract. In t...

Silidianin

Silydianin

(1R,3R,6R,7R,10R)-3-Hydroxy-10-(4-hydroxy-3-methoxyphenyl)-8-[(2R,3R)-3,5,7-trihydroxy-4-oxo-3,4-dihydro-2H-chromen-2-yl]-4-oxatricyclo[4.3.1.0]dec-8-en-2-one

Silydianin (20 mg)

Silychristin

3,6-Methanobenzofuran-7(6H)-one, 4-[(2R,3R)-3,4-dihydro-3,5,7-trihydroxy-4-oxo-2H-1-benzopyran-2-yl]-2,3,3a,7a-tetrahydro-7a-hydroxy-8-(4-hydroxy-3-methoxyphenyl)-, (3R,3aR,6R,7aR,8R)-