4alpha-PDD
4alpha-PDD structure
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Common Name | 4alpha-PDD | ||
|---|---|---|---|---|
| CAS Number | 27536-56-7 | Molecular Weight | 672.93100 | |
| Density | 1.14g/cm3 | Boiling Point | 734.2ºC at 760mmHg | |
| Molecular Formula | C40H64O8 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 212.4ºC | |
| Symbol |
GHS06, GHS08 |
Signal Word | Danger | |
Use of 4alpha-PDD4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1]. |
| Name | 4alpha-phorbol 12,13-didecanoate |
|---|---|
| Synonym | More Synonyms |
| Description | 4α-Phorbol 12,13-didecanoate (4αPDD) is a TRPV4 agonist with antidipsogenic effects. 4α-Phorbol 12,13-didecanoate promotes Ca2+ influx[1]. |
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| Related Catalog | |
| References |
| Density | 1.14g/cm3 |
|---|---|
| Boiling Point | 734.2ºC at 760mmHg |
| Molecular Formula | C40H64O8 |
| Molecular Weight | 672.93100 |
| Flash Point | 212.4ºC |
| Exact Mass | 672.46000 |
| PSA | 130.36000 |
| LogP | 7.31330 |
| Vapour Pressure | 6.92E-25mmHg at 25°C |
| Index of Refraction | 1.546 |
| Storage condition | -20°C |
| Symbol |
GHS06, GHS08 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H300 + H310 + H330-H334-H351 |
| Precautionary Statements | P260-P264-P280-P284-P301 + P310-P302 + P350 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T+: Very toxic; |
| Risk Phrases | 26/27/28-40-43 |
| Safety Phrases | 36/37/39-45 |
| RIDADR | UN 2811 6.1/PG 2 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
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Involvement of TRPV1 and TRPV4 channels in migration of rat pulmonary arterial smooth muscle cells.
Pflugers Arch. 464(3) , 261-72, (2012) Pulmonary hypertension, the main disease of the pulmonary circulation, is characterized by an increase in pulmonary vascular resistance, involving proliferation and migration of pulmonary arterial smo... |
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Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium.
Am. J. Physiol. Lung Cell. Mol. Physiol. 297(4) , L650-7, (2009) Pulmonary vascular endothelial cells express a variety of ion channels that mediate Ca(2+) influx in response to diverse environmental stimuli. However, it is not clear whether Ca(2+) influx from disc... |
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Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication.
Hypertension 53(2) , 228-35, (2009) To test the hypothesis that activation of the transient receptor potential vanilloid 4 (TRPV4) channel conveys a hypotensive effect that is enhanced during salt load, male Wistar rats fed a normal-sod... |
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