PALGLY

Modify Date: 2024-01-02 15:22:27

PALGLY Structure
PALGLY structure
Common Name PALGLY
CAS Number 2441-41-0 Molecular Weight 313.48
Density 1.0±0.1 g/cm3 Boiling Point 491.8±28.0 °C at 760 mmHg
Molecular Formula C18H35NO3 Melting Point N/A
MSDS USA Flash Point 251.2±24.0 °C

 Use of PALGLY


Palmitoylglycine, a novel endogenous lipid, acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Palmitoylglycine induces transient influx of calcium followed by nitric oxide production via calcium-sensitive nitric-oxide synthase enzymes. Palmitoylglycine potently inhibits heat-evoked firing of nociceptive neurons in rat dorsal horn[1].

 Names

Name 2-(hexadecanoylamino)acetic acid
Synonym More Synonyms

 PALGLY Biological Activity

Description Palmitoylglycine, a novel endogenous lipid, acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Palmitoylglycine induces transient influx of calcium followed by nitric oxide production via calcium-sensitive nitric-oxide synthase enzymes. Palmitoylglycine potently inhibits heat-evoked firing of nociceptive neurons in rat dorsal horn[1].
Related Catalog
References

[1]. Neta Rimmerman, et al. N-palmitoyl glycine, a novel endogenous lipid that acts as a modulator of calcium influx and nitric oxide production in sensory neurons. Mol Pharmacol. 2008 Jul;74(1):213-24.

 Chemical & Physical Properties

Density 1.0±0.1 g/cm3
Boiling Point 491.8±28.0 °C at 760 mmHg
Molecular Formula C18H35NO3
Molecular Weight 313.48
Flash Point 251.2±24.0 °C
Exact Mass 313.261688
PSA 66.40000
LogP 6.03
Appearance of Characters white to off-white
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.468
Storage condition 2-8°C
Water Solubility DMSO: >10mg/mL

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;half-mask respirator (US);multi-purpose combination respirator cartridge (US)
RIDADR NONH for all modes of transport
HS Code 2924199090

 Synthetic Route

~76%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: McIlhinney; Harvey Journal of Mass Spectrometry, 1995 , vol. 30, # 6 p. 900 - 910

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PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Dang, Hung The; Kang, Gyeoung Jin; Yoo, Eun Sook; Hong, Jongki; Choi, Jae Sue; Kim, Hyung Sik; Chung, Hae Young; Jung, Jee H. Bioorganic and Medicinal Chemistry, 2011 , vol. 19, # 4 p. 1520 - 1527

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PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Duarte, Rodrigo Da Costa; Ongaratto, Renata; Piovesan, Luciana Almeida; De Lima, Vania Rodrigues; Soldi, Valdir; Merlo, Aloir Antonio; D'Oca, Marcelo G. Montes Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2454 - 2460

~%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Bondi; Frankl Biochemische Zeitschrift, 1909 , vol. 17, p. 552
Detail
Literature: Conopco, Inc., d/b/a UNILEVER Patent: US2007/299269 A1, 2007 ; Location in patent: Page/Page column 5-6; 7 ;

~%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Iyer, Venkataraman N.; Sheth, Geeta N.; Subrahmanyam, V. V. R. Journal of the Indian Chemical Society, 1982 , vol. 59, # 7 p. 856 - 859

~%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: KYUSHU UNIVERSITY; NISSAN CHEMICAL INDUSTRIES, LTD. Patent: US2012/35108 A1, 2012 ;

~%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Duarte, Rodrigo Da Costa; Ongaratto, Renata; Piovesan, Luciana Almeida; De Lima, Vania Rodrigues; Soldi, Valdir; Merlo, Aloir Antonio; D'Oca, Marcelo G. Montes Tetrahedron Letters, 2012 , vol. 53, # 19 p. 2454 - 2460

~%

PALGLY Structure

PALGLY

CAS#:2441-41-0

Literature: Abderhalden; Funk Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, 1910 , vol. 65, p. 66

 Customs

HS Code 2924199090
Summary 2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

 Articles13

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GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination.

PLoS ONE 8 , e60314, (2013)

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Glycine N-acyltransferase-like 3 is responsible for long-chain N-acylglycine formation in N18TG2 cells.

J. Lipid Res. 57 , 781-90, (2016)

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 Synonyms

N-Ethanoyl-Hexadecanamide
PALGLY
N-hexadecanoyl glycine
Palmitoylglycine
QV1MV15
N-palmitatoylglycyne
N-(1-Oxohexadecyl)glycine
N-Hexadecanoylglycine
Glycine, N-(1-oxohexadecyl)-
Hexadecanoylaminoacetic acid N-palmitoyl glycine
Hexadecanoylaminoacetic acid,N-palmitoyl glycine
2-(Hexadecanoylamino)acetic acid
N-palmitoyl glycine
N-Palmitoylglycine
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