Lawsone methyl ether

Modify Date: 2024-01-07 18:33:20

Lawsone methyl ether structure	Common Name	Lawsone methyl ether
	CAS Number	2348-82-5	Molecular Weight	188.17900
	Density	1.28g/cm3	Boiling Point	339.8ºC at 760mmHg
	Molecular Formula	C₁₁H₈O₃	Melting Point	184-187ºC(lit.)
	MSDS	Chinese USA	Flash Point	152.7ºC
	Symbol	GHS07	Signal Word	Warning

Use of Lawsone methyl ether

Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities[1].

Name	2-methoxy-1,4-naphthoquinone
Synonym	More Synonyms

Description	Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone), isolated from Impatiens balsamina L. and Swertia calycina, exhibits potent antifungal and antibacterial activities[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	The value of both minimal inhibitory concentration and minimal fungicidal concentration of Lawsone methyl ether (2-Methoxy-1,4-naphthoquinone) against Candida was 1.25 lg⁄ml[1].
References	[1]. Sritrairat N, et al. Antifungal activity of lawsone methyl ether in comparison with chlorhexidine. J Oral Pathol Med. 2011 Jan;40(1):90-6.

Density	1.28g/cm3
Boiling Point	339.8ºC at 760mmHg
Melting Point	184-187ºC(lit.)
Molecular Formula	C₁₁H₈O₃
Molecular Weight	188.17900
Flash Point	152.7ºC
Exact Mass	188.04700
PSA	43.37000
LogP	1.59590
Vapour Pressure	8.98E-05mmHg at 25°C
Index of Refraction	1.589
Storage condition	-20℃

Lawsone methyl ether MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL8960000

CHEMICAL NAME :: 1,4-Naphthoquinone, 2-methoxy-

CAS REGISTRY NUMBER :: 2348-82-5

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C11-H8-O3

MOLECULAR WEIGHT :: 188.19

WISWESSER LINE NOTATION :: L66 BV EVJ CO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 320 mg/kg

TOXIC EFFECTS :: Tumorigenic - active as anti-cancer agent

REFERENCE :: JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 26,570,1983

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 316 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	36/37/38
Safety Phrases	S26;S36
RIDADR	NONH for all modes of transport
RTECS	QL8960000
HS Code	2914690090

Precursor 10
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CAS#:824-46-4 2-methoxyhydroq... CAS#:67-56-1 Methanol CAS#:2065-37-4 1,4-Naphthalene... CAS#:70477-38-2 3,4-dimethoxyna...
CAS#:60683-53-6 1,2,4-trimethox... CAS#:83-72-7 2-Hydroxy-1,4-n...
DownStream 10
CAS#:104202-35-9 2-methoxy-3-pro... CAS#:33440-64-1 bi-lawsone CAS#:14422-78-7 1,4-Naphthalene... CAS#:26037-61-6 2-bromo-3-metho...
CAS#:84-79-7 Lapachol CAS#:3408-13-7 2-(1,4-dioxonap... CAS#:3144-89-6 1,4-Naphthalene... CAS#:17241-45-1 1,4-Naphthalene...
CAS#:24555-42-8 2-morpholin-4-y... CAS#:75112-65-1 2-[(4-nitrophen...

HS Code	2914690090
Summary	2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

2-Methoxy-1,4-naphthoquinone (MNQ) induces apoptosis of A549 lung adenocarcinoma cells via oxidation-triggered JNK and p38 MAPK signaling pathways.

Life Sci. 135 , 158-64, (2015)

The compound 2-methoxy-1,4-naphthoquinone (MNQ) was previously shown to be cytotoxic against several cancer cell lines, but its mode of action is poorly understood. In this study, we aimed to explore ...

Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.

Fitoterapia 83(8) , 1336-44, (2012)

2-Methoxy-1,4-naphthoquinone (MeONQ) from Impatiens balsamina L. exhibited strong anti-H. pylori activity in our previous study. In this study, we investigated the cytotoxicity of MeONQ against gastri...

Effects of the compounds 2-methoxynaphthoquinone, 2-propoxynaphthoquinone, and 2-isopropoxynaphthoquinone on ecdysone 20-monooxygenase activity.

Arch. Insect Biochem. Physiol. 66(1) , 45-52, (2007)

The effects of the natural compound 2-methoxy-1,4-naphthoquinone, isolated from the leaves of Impatiens glandulifera and the synthetic compounds 2-propoxy-1,4-naphthoquinone and 2-isopropoxy-1,4-napht...

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BioBioPha
China
Product Name: 2-Methoxy-1,4-naphthoquinone
Price: ￥Inquiry/5mg
Purity: 98.0%
Stocking Period: 1 Day
Contact: Xueping-Zheng

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1,4-Naphthalenedione,2-methoxy-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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