(S)-Indoximod

Modify Date: 2024-01-02 19:24:38

(S)-Indoximod structure	Common Name	(S)-Indoximod
	CAS Number	21339-55-9	Molecular Weight	218.252
	Density	1.28	Boiling Point	429.3±35.0 °C at 760 mmHg
	Molecular Formula	C₁₂H₁₄N₂O₂	Melting Point	223-226 ºC
	MSDS	Chinese USA	Flash Point	213.4±25.9 °C

Use of (S)-Indoximod

(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].

Name	(2S)-2-amino-3-(1-methylindol-3-yl)propanoic acid
Synonym	More Synonyms

Description	(S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2,3-dioxygenase (IDO). (S)-Indoximod can be used for the research of cancer[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Metabolic Enzyme/Protease >> Indoleamine 2,3-Dioxygenase (IDO)
Target	Indoleamine 2,3-Dioxygenase (IDO)[1]
References	[1]. Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719. [2]. Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.

Density	1.28
Boiling Point	429.3±35.0 °C at 760 mmHg
Melting Point	223-226 ºC
Molecular Formula	C₁₂H₁₄N₂O₂
Molecular Weight	218.252
Flash Point	213.4±25.9 °C
Exact Mass	218.105530
PSA	68.25000
LogP	1.43
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.625
Storage condition	2-8°C

(S)-Indoximod MSDS(Chinese)

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YN7135000

CHEMICAL NAME :: L-Tryptophan, 1-methyl-

CAS REGISTRY NUMBER :: 21339-55-9

LAST UPDATED :: 198910

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H14-N2-O2

MOLECULAR WEIGHT :: 218.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 286 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JTEHD6 Journal of Toxicology and Environmental Health. (Hemisphere Pub., 1025 Vermont Ave., NW, Washington, DC 20005) V.1- 1975/76- Volume(issue)/page/year: 1,515,1976

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R20/21/22
Safety Phrases	36
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YN7135000
HS Code	2933990090

L(-)-Tryptophan

CAS#:73-22-3

methyl iodide

CAS#:74-88-4

~92%

(S)-Indoximod

CAS#:21339-55-9

Literature: He, Bin; Song, Hao; Du, Yu; Qin, Yong Journal of Organic Chemistry, 2009 , vol. 74, # 1 p. 298 - 304

L(-)-Tryptophan

CAS#:73-22-3

(S)-Indoximod

CAS#:21339-55-9

Literature: Bioorganic and Medicinal Chemistry Letters, , vol. 12, # 17 p. 2471 - 2474

Precursor 2
CAS#:73-22-3 L(-)-Tryptophan CAS#:74-88-4 methyl iodide
DownStream 0

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Human renal tubular epithelial cells suppress alloreactive T cell proliferation.

Clin. Exp. Immunol. 179(3) , 509-19, (2015)

Renal tubular epithelial cells (TECs) are one of the main targets of alloreactive T cells during acute rejection. We hypothesize that TECs modulate the outcome of alloimmunity by executing immunosuppr...

Induction of indoleamine 2,3-dioxygenase (IDO) enzymatic activity contributes to interferon-gamma induced apoptosis and death receptor 5 expression in human non-small cell lung cancer cells.

Asian Pac. J. Cancer Prev. 15(18) , 7995-8001, (2014)

Interferon-gamma (IFN-γ) has been used to treat various malignant tumors. However, the molecular mechanisms underlying the direct anti-proliferative activity of IFN-γ are poorly understood. In the pre...

Interferon gamma-mediated BoHV-4 replication restriction in bovine endometrial stromal cells is host IDO1 gene expression independent and BoHV-4 IE2 gene expression dependent.

Biol. Reprod. 91(5) , 112, (2014)

In the present work the interaction between bovine herpesvirus 4 (BoHV-4)-infected bovine endometrial stromal cells (BESCs) and interferon gamma (IFNG) was investigated. Starting from the particular t...

1-Methyl-L-tryptophan

DL-1-Methyltryptophan

MFCD00467133

L-Tryptophan, 1-methyl-

1-methyl-(D,L)-tryptophan

1-Methyl-L-tryptophane

H-L-Trp(N-CH3)-OH

H-Trp(1-Me)-OH

BIDD:GT0440

(S)-2-Amino-3-(1-methyl-1H-indol-3-yl)propanoic acid

GL Biochem (Shanghai) Ltd.
China
Product Name: 1-Methyl-L-tryptophan
Price: ￥Inquiry/1kg ￥Inquiry/100g
Purity: 99.0%
Stocking Period: Inquiry
Contact: Jackie Yang

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: (S)-Indoximod
Price: ￥198.0/20mg
Purity: 98.0%
Stocking Period: 2 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: 1-Methyl-L-tryptophan
Price: $280.0/20mg
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Nanjing Peptide Biotech Ltd
China
Product Name: 1-Methyl-L-tryptophan
Price: ￥Inquiry/10g ￥Inquiry/100g ￥Inquiry/1kg ￥Inquiry/10kg
Purity: 98.0%
Stocking Period: 7 Day
Contact: jom

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 1-Methyl-L-tryptophan
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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(S)-Indoximod

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