GS-2989

Modify Date: 2024-01-14 15:16:44

GS-2989 Structure
GS-2989 structure
Common Name GS-2989
CAS Number 2013-58-3 Molecular Weight 476.86
Density 1.72g/cm3 Boiling Point 716.4ºC at 760mmHg
Molecular Formula C22H21ClN2O8 Melting Point N/A
MSDS N/A Flash Point 387.1ºC

 Use of GS-2989


Meclocycline is a tetracycline derivative. The main target of tetracyclines is the bacterial ribosome[1].

 Names

Name meclocycline
Synonym More Synonyms

 GS-2989 Biological Activity

Description Meclocycline is a tetracycline derivative. The main target of tetracyclines is the bacterial ribosome[1].
Related Catalog
References

[1]. Fuoco D. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, et al. Cytotoxicity induced by tetracyclines via protein photooxidation[J]. Advances in Toxicology, 2015, 2015.

 Chemical & Physical Properties

Density 1.72g/cm3
Boiling Point 716.4ºC at 760mmHg
Molecular Formula C22H21ClN2O8
Molecular Weight 476.86
Flash Point 387.1ºC
Exact Mass 476.09900
PSA 181.62000
LogP 0.91580
Vapour Pressure 0mmHg at 25°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QI7830000
CHEMICAL NAME :
2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octah ydro- 3,5,10,12,12a-pentahydroxy-6-methylene-1,11-dioxo-
CAS REGISTRY NUMBER :
2013-58-3
LAST UPDATED :
198803
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C22-H21-Cl-N2-O8

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 22,1022,1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
425 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
GICTAL Giornale Italiano di Chemioterapia. Italian Journal of Chemotherapy. (Edizioni Minerva Medica, Casella Postale 491, I-10126 Turin, Italy) V.1- 1954- Volume(issue)/page/year: 17,276,1970

 Synonyms

meclocyline
Meclocycline(usan)
GS-2989
Meclocycline base
Chlormethylenecycline
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  • Purity: 98.0%
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