Azido-PEG3-maleimide
Modify Date: 2024-01-10 23:39:16
Azido-PEG3-maleimide structure
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Common Name | Azido-PEG3-maleimide | ||
|---|---|---|---|---|
| CAS Number | 1858264-36-4 | Molecular Weight | 369.373 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C15H23N5O6 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Azido-PEG3-maleimideAzido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
| Name | (1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid |
|---|---|
| Synonym | More Synonyms |
| Description | Azido-PEG3-maleimide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG3-maleimide is also a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2]. |
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| Related Catalog | |
| Target |
PEGs Cleavable |
| In Vitro | PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2]. |
| References |
| Molecular Formula | C15H23N5O6 |
|---|---|
| Molecular Weight | 369.373 |
| Exact Mass | 369.164825 |
| LogP | -0.60 |
| (1Z)-N-(2-{2-[2-(2-Azidoethoxy)ethoxy]ethoxy}ethyl)-3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanimidic acid |
| 1H-Pyrrole-1-propanimidic acid, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethyl]-2,5-dihydro-2,5-dioxo- |