PD 151746
Modify Date: 2024-01-01 19:01:30
PD 151746 structure
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Common Name | PD 151746 | ||
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| CAS Number | 179461-52-0 | Molecular Weight | 237.25000 | |
| Density | 1.525±0.06 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H8FNO2S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
Use of PD 151746PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1]Target: calpainin vitro: The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2] |
| Name | 2-Propenoic acid, 3-(5-fluoro-1H-indol-3-yl)-2-mercapto- |
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| Synonym | More Synonyms |
| Description | PD151746 is a calpain inhibitor, shows a 20-fold selectivity for u-calpain (Ki = 0.26 ± 0.03 μM) over m-calpain (Ki = 5.33 ± 0.77 μM).IC50 value: 0.26 ± 0.03 μM (Ki, for μ-calpain), 5.33 ± 0.77 μM (Ki, for m-calpain) [1]Target: calpainin vitro: The μ-calpain inhibitor PD 151746 decreases oxLDL-induced cytotoxicity. [2] |
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| Related Catalog | |
| Cell Assay | HMEC-1 cells cultured in 60-mm-diameter culture dishes were left untreated or were exposed to 200 μg/ml oxLDL for 20 h or to 200 nM staurosporine (STS) for 4 h. Along with oxLDL, some cells were co-treated with PD 151746 (20 μM) or BAF (50 μM). Thereafter, the cells were harvested and processed for Western blotting as described in the Experimental section. The PVDF membrane was probed with an anti-α-fodrin mAb. The absorbance (A) of the 150 and 120 kDa bands was scanned, and the ratio of the two values (A 150/A 120) is indicated below relevant samples. The illustrated blot is representative of five separate experiments[2]. |
| References |
| Density | 1.525±0.06 g/cm3 |
|---|---|
| Molecular Formula | C11H8FNO2S |
| Molecular Weight | 237.25000 |
| Exact Mass | 237.02600 |
| PSA | 91.89000 |
| LogP | 2.66230 |
| Appearance of Characters | powder,light orange to dark orange |
| Storage condition | -20°C |
| Water Solubility | Very slightly soluble (0.28 g/L) (25 ºC) |
| Safety Phrases | 24/25 |
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| RIDADR | 3077 |
| WGK Germany | 3 |
| PD 151746 |
| 3-(5-Fluoro-1H-indol-3-yl)-2-mercapto-2-propenoic acid |