SNC 162

Modify Date: 2024-01-28 19:05:34

SNC 162 structure	Common Name	SNC 162
	CAS Number	178803-51-5	Molecular Weight	419.60
	Density	1.027g/cm3	Boiling Point	536.4ºC at 760mmHg
	Molecular Formula	C₂₇H₃₇N₃O	Melting Point	N/A
	MSDS	N/A	Flash Point	202.4ºC

Use of SNC 162

SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2].

Name	4-[(S)-[(2S,5R)-2,5-Dimethyl-4-(2-propenyl)-1-piperazinyl]phenylmethyl]-N,N-diethylbenzamide
Synonym	More Synonyms

Description	SNC162 is a delta-opioid receptor agonist with an IC50 of 0.94 nM. SNC162 has antidepressant-like effects and produces a selective enhancement of the antinociceptive effects of fentanyl in rhesus monkeys[1][2].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease
Target	IC50: 0.94 nM (delta-opioid receptor)[1]
References	[1]. Jutkiewicz EM, et al. Delta-opioid agonists: differential efficacy and potency of SNC80, its 3-OH (SNC86) and 3-desoxy (SNC162) derivatives in Sprague-Dawley rats. J Pharmacol Exp Ther. 2004 Apr;309(1):173-81. [2]. Banks ML, et al. Selective enhancement of fentanyl-induced antinociception by the delta agonist SNC162 but not by ketamine in rhesus monkeys: Further evidence supportive of delta agonists as candidate adjuncts to mu opioid analgesics. Pharmacol Biochem Behav. 2010 Dec;97(2):205-12.

Density	1.027g/cm3
Boiling Point	536.4ºC at 760mmHg
Molecular Formula	C₂₇H₃₇N₃O
Molecular Weight	419.60
Flash Point	202.4ºC
Exact Mass	419.29400
PSA	26.79000
LogP	4.71440
Vapour Pressure	1.4E-11mmHg at 25°C
Index of Refraction	1.549

4-(Phenylcarbonyl)benzoic Acid structure

4-(Phenylcarbon...

CAS#:611-95-0

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SNC 162 Structure

SNC 162

CAS#:178803-51-5

Literature: Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704

4-benzoyl-N,N-diethylbenzamide structure

4-benzoyl-N,N-d...

CAS#:67055-76-9

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SNC 162 Structure

SNC 162

CAS#:178803-51-5

Literature: Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704

N/A structure

N/A

CAS#:186094-07-5

~%

SNC 162 Structure

SNC 162

CAS#:178803-51-5

Literature: Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704

(2R,5S)-2,5-Dimethylpiperazine structure

(2R,5S)-2,5-Dim...

CAS#:2815-34-1

~%

SNC 162 Structure

SNC 162

CAS#:178803-51-5

Literature: Calderon, Silvia N.; Rice, Kenner C.; Rothman, Richard B.; Porreca, Frank; Flippen-Anderson, Judith L.; Kayakiri, Hiroshi; Xu, Heng; Becketts, Karen; Smith, Larren E.; Bilsky, Edward J.; Davis, Peg; Horvath, Robert Journal of Medicinal Chemistry, 1997 , vol. 40, # 5 p. 695 - 704

Precursor 3
CAS#:611-95-0 4-(Phenylcarbon... CAS#:67055-76-9 4-benzoyl-N,N-d... CAS#:2815-34-1 (2R,5S)-2,5-Dim...
DownStream 0

snc 162

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: 4-[(S)-[(2S,5R)-2,5-DIMETHYL-4-(2-PROPENYL)-1-PIPERAZINYL]PHENYLMETHYL]-N,N-DIETHYLBENZAMIDE
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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