IRL-2500

Modify Date: 2024-01-03 08:11:38

IRL-2500 structure	Common Name	IRL-2500
	CAS Number	169545-27-1	Molecular Weight	573.68100
	Density	1.246g/cm3	Boiling Point	893.7ºC at 760mmHg
	Molecular Formula	C₃₆H₃₅N₃O₄	Melting Point	83-88ºC
	MSDS	N/A	Flash Point	494.3ºC

Use of IRL-2500

IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1].

Name	(2S)-2-[[(2R)-2-[(3,5-dimethylbenzoyl)-methylamino]-3-(4-phenylphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acid
Synonym	More Synonyms

Description	IRL 2500 is a potent Endothelin receptor antagonist. IRL 2500 shows IC50 values of 1.3 and 94 nM for ETB and ETA receptors, respectively. IRL 2500 inhibits ETB receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo[1].
Related Catalog	Research Areas >> Cardiovascular Disease Signaling Pathways >> GPCR/G Protein >> Endothelin Receptor
Target	ETB:1.3 nM (IC50) ETA:94 nM (IC50)
In Vivo	IRL 2500 (intravenous injection;10 mg/kg) inhibits the initial transient decrease in mean arterial pressure (MAP) induced by the ETB-selective agonist IRL 1620 in rats, IRL 2500 also attenuates the IRL 1620-mediated increase in renal vascular resistance (RVR) in the anesthetized rat[1]. IRL 2500 (intravenous injection;10 mg/kg) pre-reatment significantly reduces the initial vasodepressor response to endothelin-1 (ET-1) and IRL 1620, however, it is not alters the secondary and sustained pressor response to these agonists[2].
References	[1]. Balwierczak JL, et al. Characterization of a potent and selective endothelin-B receptor antagonist, IRL 2500.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S393-6. [2]. Webb RL, et al. Effects of the ETB-selective antagonist IRL 2500 in conscious spontaneously hypertensive and Wistar-Kyoto rats.J Cardiovasc Pharmacol. 1995;26 Suppl 3:S389-92.

Density	1.246g/cm3
Boiling Point	893.7ºC at 760mmHg
Melting Point	83-88ºC
Molecular Formula	C₃₆H₃₅N₃O₄
Molecular Weight	573.68100
Flash Point	494.3ºC
Exact Mass	573.26300
PSA	102.50000
LogP	6.33800
Vapour Pressure	2.56E-34mmHg at 25°C
Index of Refraction	1.652
Storage condition	2-8°C

Tocris-1838

IRL-2500

DC Chemicals Limited
China
Product Name: IRL 2500
Price:
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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Price: ￥1550/1 mg

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IRL-2500

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