WAY-100135 structure
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Common Name | WAY-100135 | ||
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CAS Number | 149055-79-8 | Molecular Weight | 468.46000 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C24H35Cl2N3O2 | Melting Point | N/A | |
MSDS | Chinese USA | Flash Point | N/A |
Use of WAY-100135WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2]. |
Name | N-tert-Butyl-3-(4-(2-methoxyphenyl)-piperazin-1-yl) -2-phenylpropanamide dihydrochloride |
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Synonym | More Synonyms |
Description | WAY-100135 dihydrochloride is a selective antagonist at presynaptic and postsynaptic 5-HT1A receptor, with an IC50 of 34 nM at the rat hippocampal 5-HT1A receptor. WAY-100135 dihydrochloride has potential antipsychotic properties[1][2]. |
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Related Catalog | |
Target |
5-HT1A Receptor:34 nM (IC50) |
In Vitro | WAY100135 (0.1-1 μM) antagonises electrically evoked contractions of 5-carboxamidoiodotryptamine in the guinea-pig ileum, with a pA2 of 7.2[1]. WAY-100135 dihydrochloride (10 μM) blocks the suppressive effect of 8-OH-DPAT on eEPSC and eIPSC in MVM neurons[2]. |
In Vivo | WAY100135 (2.5 mg/kg) induces a maximum 30% inhibition of raphe neuronal firing and (0.5 mg/kg i.v.) antagonises the inhibition of firing induced by 8-OH-DPAT in anaesthetised rats[1]. WAY-100135 dihydrochloride (10 mM; 1 μL for microinjection) effectively abolishes all 5-HT induced behavioural deficits in rats[2]. |
References |
Molecular Formula | C24H35Cl2N3O2 |
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Molecular Weight | 468.46000 |
Exact Mass | 467.21100 |
PSA | 48.30000 |
LogP | 5.96290 |
RIDADR | NONH for all modes of transport |
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3-[4-(2-Methoxyphenyl)piperazin-1-yl]-2-phenyl-N-tert-butyl-propanamide dihydrochloride |
N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide,dihydrochloride |
WAY-100135 dihydrochloride |