3,4-Dimethoxycinnamic acid

Modify Date: 2024-01-05 10:04:07

3,4-Dimethoxycinnamic acid Structure
3,4-Dimethoxycinnamic acid structure
Common Name 3,4-Dimethoxycinnamic acid
CAS Number 14737-89-4 Molecular Weight 208.211
Density 1.2±0.1 g/cm3 Boiling Point 367.4±27.0 °C at 760 mmHg
Molecular Formula C11H12O4 Melting Point 181-183ºC(lit.)
MSDS N/A Flash Point 144.0±17.2 °C

 Use of 3,4-Dimethoxycinnamic acid


(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].

 Names

Name 3,4-dimethoxycinnamic acid
Synonym More Synonyms

 3,4-Dimethoxycinnamic acid Biological Activity

Description (E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid. 3,4-Dimethoxycinnamic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway[1]. Anti-apoptotic effects[1].
Related Catalog
In Vitro 3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced apoptosis of ethanolexposed L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells[1]. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells[1]. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of caspase-3 in a dose- and time-dependent manner[1].
References

[1]. Li L, et al. Methyl ferulic acid exerts anti-apoptotic effects on L-02 cells via the ROS-mediated signalingpathway. Int J Oncol. 2018 Jul;53(1):225-236.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 367.4±27.0 °C at 760 mmHg
Melting Point 181-183ºC(lit.)
Molecular Formula C11H12O4
Molecular Weight 208.211
Flash Point 144.0±17.2 °C
Exact Mass 208.073563
PSA 55.76000
LogP 2.24
Vapour Pressure 0.0±0.9 mmHg at 25°C
Index of Refraction 1.574

 Safety Information

Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases 37/39-26
WGK Germany 3

 Synthetic Route

 Synonyms

O-methylfagaronine chloride
2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-
O-methylfagaronine
EINECS 219-025-5
3,4-DIMETHOXYCINNAMIC ACID
O-Methylferulic acid
MFCD00004387
3-(3,4-Dimethoxyphenyl)acrylic acid
2-Methoxyfagaronine
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