Isopropyl palmitate

Modify Date: 2024-01-02 11:44:09

Isopropyl palmitate Structure
Isopropyl palmitate structure
Common Name Isopropyl palmitate
CAS Number 142-91-6 Molecular Weight 298.51
Density 0.9±0.1 g/cm3 Boiling Point 340.7±10.0 °C at 760 mmHg
Molecular Formula C19H38O2 Melting Point 11-13 °C(lit.)
MSDS Chinese USA Flash Point 162.2±8.8 °C

 Use of Isopropyl palmitate


Isopropyl palmitate is an fatty acid ester. Isopropyl palmitate can be used for design and characterization of bioactive bilayer films. The bilayer membrane not only has the ability to scavenge free radicals and inhibit lipid peroxidation, but also can inhibit the growth of known foodborne pathogens. Isopropyl palmitate can be used as an excipient, such as lubricant, oily carrier, solvent, controlled-release transdermal film. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].

 Names

Name isopropyl palmitate
Synonym More Synonyms

 Isopropyl palmitate Biological Activity

Description Isopropyl palmitate is an fatty acid ester. Isopropyl palmitate can be used for design and characterization of bioactive bilayer films. The bilayer membrane not only has the ability to scavenge free radicals and inhibit lipid peroxidation, but also can inhibit the growth of known foodborne pathogens. Isopropyl palmitate can be used as an excipient, such as lubricant, oily carrier, solvent, controlled-release transdermal film. Pharmaceutical excipients, or pharmaceutical auxiliaries, refer to other chemical substances used in the pharmaceutical process other than pharmaceutical ingredients. Pharmaceutical excipients generally refer to inactive ingredients in pharmaceutical preparations, which can improve the stability, solubility and processability of pharmaceutical preparations. Pharmaceutical excipients also affect the absorption, distribution, metabolism, and elimination (ADME) processes of co-administered drugs[1][2].
Related Catalog
References

[1]. Luís Â, et al. Design and Characterization of Bioactive Bilayer Films: Release Kinetics of Isopropyl Palmitate. Antibiotics (Basel). 2020 Jul 24;9(8):443.  

[2]. Elder DP, et al. Pharmaceutical excipients - quality, regulatory and biopharmaceutical considerations. Eur J Pharm Sci. 2016 May 25;87:88-99.  

 Chemical & Physical Properties

Density 0.9±0.1 g/cm3
Boiling Point 340.7±10.0 °C at 760 mmHg
Melting Point 11-13 °C(lit.)
Molecular Formula C19H38O2
Molecular Weight 298.51
Flash Point 162.2±8.8 °C
Exact Mass 298.287170
PSA 26.30000
LogP 8.49
Vapour Pressure 0.0±0.7 mmHg at 25°C
Index of Refraction 1.443
Storage condition 2-8°C

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
RT4900000
CHEMICAL NAME :
Palmitic acid, isopropyl ester
CAS REGISTRY NUMBER :
142-91-6
BEILSTEIN REFERENCE NO. :
1786567
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C19-H38-O2
MOLECULAR WEIGHT :
298.57
WISWESSER LINE NOTATION :
15VOY1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Human
REFERENCE :
85DKA8 "Cutaneous Toxicity, Proceedings of the 3rd Conference, 1976," Drill, V.A., and P. Lazar, eds., New York, Academic Press, Inc. 1977 Volume(issue)/page/year: -,127,1977
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 20,727,1982 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82948 No. of Facilities: 1596 (estimated) No. of Industries: 18 No. of Occupations: 43 No. of Employees: 75810 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82948 No. of Facilities: 2360 (estimated) No. of Industries: 18 No. of Occupations: 48 No. of Employees: 200948 (estimated) No. of Female Employees: 162709 (estimated)

 Safety Information

Personal Protective Equipment Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xi:Irritant
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany -
RTECS RT4900000
HS Code 2915709000

 Synthetic Route

~65%

Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: US2004/106813 A1, ; Page 3 ;

~98%

Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Burger; Greyling; Spies Journal of Chemical Ecology, 1999 , vol. 25, # 9 p. 2099 - 2108

~%

Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Journal of the American Oil Chemists' Society, , vol. 24, p. 257

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Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Journal of Organic Chemistry, , vol. 78, # 6 p. 2386 - 2396

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Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Australian Journal of Chemistry, , vol. 30, p. 2487 - 2492

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Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Australian Journal of Chemistry, , vol. 30, p. 2487 - 2492

~%

Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: Australian Journal of Chemistry, , vol. 30, p. 2487 - 2492

~%

Isopropyl palmitate Structure

Isopropyl palmitate

CAS#:142-91-6

Literature: JAOCS, Journal of the American Oil Chemists' Society, , vol. 81, # 4 p. 331 - 337

 Customs

HS Code 2915709000
Summary 2915709000. palmitic acid and its salts and esters. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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 Synonyms

Hexadecanoic acid 1-methylethyl ester
Isopropyl hexadecanoate
Hexadecanoic acid, 1-methylethyl ester
Isopropyl palmitate
Palmitic Acid Isopropyl Ester
propan-2-yl hexadecanoate
MFCD00008993
EINECS 205-571-1
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