Tyrphostin AG 528

Modify Date: 2024-05-01 19:00:31

Tyrphostin AG 528 Structure
Tyrphostin AG 528 structure
Common Name Tyrphostin AG 528
CAS Number 133550-49-9 Molecular Weight 306.31500
Density N/A Boiling Point N/A
Molecular Formula C18H14N2O3 Melting Point 215 °C
MSDS USA Flash Point N/A

 Use of Tyrphostin AG 528


Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.

 Names

Name Tyrphostin AG 528
Synonym More Synonyms

 Tyrphostin AG 528 Biological Activity

Description Tyrphostin AG 528 is an inhibitor of EGFR and ErbB2 with IC50s of 4.9 and 2.1 μM, respectively.
Related Catalog
Target

EGFR:4.9 μM (IC50)

ErbB2:2.1 μM (IC50)

References

[1]. Naijue Zhu, et al. Tyrphostin Tumor Growth Inhibitors of EGFR and ErbB2 Tyrosine Kinase. J Chem Crystallogr. 2007, 37, 679–683.

 Chemical & Physical Properties

Melting Point 215 °C
Molecular Formula C18H14N2O3
Molecular Weight 306.31500
Exact Mass 306.10000
PSA 84.56000
LogP 2.65908

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport

 Synonyms

N-(3',4'-dihydroxybenzylidenecyanoacetyl)indoline
(E)-2-(2,3-Dihydro-indole-1-carbonyl)-3-(3,4-dihydroxy-phenyl)-acrylonitrile
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