Senecionine N-oxide

Modify Date: 2024-01-06 15:19:20

Senecionine N-oxide structure	Common Name	Senecionine N-oxide
	CAS Number	13268-67-2	Molecular Weight	351.39400
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₈H₂₅NO₆	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Senecionine N-oxide

Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

Name	Senecionine, N-oxide
Synonym	More Synonyms

Description	Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Others >> Others
References	[1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643 [2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3.

Description

Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

Related Catalog

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

References

[1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643

[2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3.

Molecular Formula	C₁₈H₂₅NO₆
Molecular Weight	351.39400
Exact Mass	351.16800
PSA	102.26000
LogP	1.16420

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT5720000

CHEMICAL NAME :: Senecionan-11,16-dione, 12-hydroxy-, 4-oxide

CAS REGISTRY NUMBER :: 13268-67-2

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: female 4-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 77,461,1988

Hazard Codes	Xi
RIDADR	UN 1544
Packaging Group	II
Hazard Class	6.1(a)

Precursor 1
CAS#:130-01-8 Senecionine
DownStream 0

12-Hydroxysenecionan-11,16-dione 4-oxide

Senecionine oxide

integerrimine N-oxide

senecionine N-oxide

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione,3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-5,6-dimethyl-,12-oxide, (3Z,5R,6R,14aR,14bR)-
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

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Senecionine N-oxide

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