Senecionine N-oxide

Names

[ Name ]:
Senecionine N-oxide

[Synonym ]:
12-Hydroxysenecionan-11,16-dione 4-oxide
Senecionine oxide
integerrimine N-oxide
senecionine N-oxide

Biological Activity

[Description]:

Senecionine n-oxide is the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Senecionine N-oxide has anti-cancer activity[1][2].

[Related Catalog]:

Research Areas >> Cancer

Signaling Pathways >> Others >> Others

[References]

[1]. Thomas Hartmann, et al. Senecionine n-oxide, the primary product of pyrrolizidine alkaloid biosynthesis in root cultures of Senecio vulgaris. Phytochemistry, Volume 26, Issue 6, 1987, Pages 1639-1643

[2]. Kupchan SM, et al. Tumor inhibitors. XXII. Senecionine and senecionine N-oxide, the active principles of Senecio triangularis. J Pharm Sci. 1967 Apr;56(4):541-3.

Chemical & Physical Properties

[ Molecular Formula ]:
C₁₈H₂₅NO₆

[ Molecular Weight ]:
351.39400

[ Exact Mass ]:
351.16800

[ PSA ]:
102.26000

[ LogP ]:
1.16420

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: VT5720000

CHEMICAL NAME :: Senecionan-11,16-dione, 12-hydroxy-, 4-oxide

CAS REGISTRY NUMBER :: 13268-67-2

LAST UPDATED :: 198912

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C18-H25-N-O5

MOLECULAR WEIGHT :: 335.44

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 140 mg/kg

SEX/DURATION :: female 4-10 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 77,461,1988

Safety Information

[ Hazard Codes ]:
Xi

[ RIDADR ]:
UN 1544

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

DownStream

Related Compounds

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