(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride

Modify Date: 2024-04-09 15:01:04

(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride Structure
(S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride structure
Common Name (S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride
CAS Number 128311-08-0 Molecular Weight 301.21
Density N/A Boiling Point N/A
Molecular Formula C14H18Cl2N2O Melting Point N/A
MSDS N/A Flash Point N/A

 Use of (S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride


(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

 Names

Name PNU-282987 S enantiomer hydrochloride
Synonym More Synonyms

  Biological Activity

Description (S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
Related Catalog
References

[1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.  

 Chemical & Physical Properties

Molecular Formula C14H18Cl2N2O
Molecular Weight 301.21
Storage condition Inert atmosphere,2-8°C

 Synonyms

MFCD32182633
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