128311-08-0

128311-08-0 structure

Name: (S)-4-Chloro-N-(quinuclidin-3-yl)benzamide hydrochloride
Chemical Name: PNU-282987 S enantiomer hydrochloride
CAS Number: 128311-08-0
Molecular Formula: C₁₄H₁₈Cl₂N₂O
Molecular Weight: 301.21
Catalog: Signaling Pathways GPCR/G Protein 5-HT Receptor
Create Date: 2022-01-12 12:04:46
Modify Date: 2024-04-09 15:01:04
(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

Name	PNU-282987 S enantiomer hydrochloride
Synonyms	MFCD32182633

Description	(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
Related Catalog	Signaling Pathways >> Membrane Transporter/Ion Channel >> nAChR Signaling Pathways >> Neuronal Signaling >> nAChR Research Areas >> Neurological Disease Signaling Pathways >> GPCR/G Protein >> 5-HT Receptor Signaling Pathways >> Neuronal Signaling >> 5-HT Receptor
References	[1]. Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.