N-Carbethoxy Piperazine

Modify Date: 2024-01-02 10:38:38

N-Carbethoxy Piperazine Structure
N-Carbethoxy Piperazine structure
Common Name N-Carbethoxy Piperazine
CAS Number 120-43-4 Molecular Weight 158.198
Density 1.1±0.1 g/cm3 Boiling Point 237.0±15.0 °C at 760 mmHg
Molecular Formula C7H14N2O2 Melting Point 120 °C
MSDS Chinese USA Flash Point 97.1±20.4 °C
Symbol GHS07
GHS07
Signal Word Warning

 Names

Name Ethyl N-piperazinecarboxylate
Synonym More Synonyms

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 237.0±15.0 °C at 760 mmHg
Melting Point 120 °C
Molecular Formula C7H14N2O2
Molecular Weight 158.198
Flash Point 97.1±20.4 °C
Exact Mass 158.105530
PSA 41.57000
LogP -0.14
Vapour Pressure 0.0±0.5 mmHg at 25°C
Index of Refraction 1.467
Water Solubility soluble

 Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TL1378000
CHEMICAL NAME :
1-Piperazinecarboxylic acid, ethyl ester
CAS REGISTRY NUMBER :
120-43-4
BEILSTEIN REFERENCE NO. :
0125780
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C7-H14-N2-O2
MOLECULAR WEIGHT :
158.23
WISWESSER LINE NOTATION :
T6M DNTJ AVO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
138 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - muscle contraction or spasticity
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 33,825,1987

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H302
Personal Protective Equipment Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
Hazard Codes Xn:Harmful;
Risk Phrases R22;R36/37/38
Safety Phrases S23-S24/25-S37/39-S26
RIDADR UN 2810 6.1/PG 3
WGK Germany 3
RTECS TL1378000
Packaging Group III
Hazard Class 6.1(b)
HS Code 29335995

 Synthetic Route

~79%

N-Carbethoxy Piperazine Structure

N-Carbethoxy Pi...

CAS#:120-43-4

Literature: Indian Journal of Chemistry, Section B: Organic Chemistry Including Medicinal Chemistry, , vol. 23, # 7 p. 650 - 654

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N-Carbethoxy Piperazine Structure

N-Carbethoxy Pi...

CAS#:120-43-4

Literature: Journal of the American Chemical Society, , vol. 75, p. 4949

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N-Carbethoxy Piperazine Structure

N-Carbethoxy Pi...

CAS#:120-43-4

Literature: Journal of the Chemical Society, , p. 50

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N-Carbethoxy Piperazine Structure

N-Carbethoxy Pi...

CAS#:120-43-4

Literature: Green Chemistry, , vol. 14, # 2 p. 326 - 329

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N-Carbethoxy Piperazine Structure

N-Carbethoxy Pi...

CAS#:120-43-4

Literature: Bioorganic and Medicinal Chemistry, , vol. 16, # 22 p. 9764 - 9771

 Customs

HS Code 2933599090
Summary 2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

 Articles1

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Antitumor activity of JS-K [O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolate] and related O2-aryl diazeniumdiolates in vitro and in vivo.

J. Med. Chem. 49 , 4356-66, (2006)

The literature provides evidence that metabolic nitric oxide (NO) release mediates the cytotoxic activities (against human leukemia and prostate cancer xenografts in mice) of JS-K, a compound of struc...

 Synonyms

N-Carbethoxy Piperazine
Ethyl N-Piperazinecarboxylate
1-Piperazinecarboxylic acid, ethyl ester
1-Ethoxycarbonylpiperazine
Ethyl Piperazine-1-Carboxylate
MFCD00005964
1-Piperazinecarboxylic Acid Ethyl Ester
EINECS 204-395-2
Ethyl 1-piperazinecarboxylate
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