FLUTRIMAZOLE

Modify Date: 2024-01-10 10:20:12

FLUTRIMAZOLE structure	Common Name	FLUTRIMAZOLE
	CAS Number	119006-77-8	Molecular Weight	346.373
	Density	1.2±0.1 g/cm3	Boiling Point	457.1±40.0 °C at 760 mmHg
	Molecular Formula	C₂₂H₁₆F₂N₂	Melting Point	161-166ºC
	MSDS	N/A	Flash Point	230.3±27.3 °C

Use of FLUTRIMAZOLE

Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].

Name	flutrimazole
Synonym	More Synonyms

Description	Flutrimazole is an imidazole antifungal with dual anti-inflammatory and antifungal activity. Flutrimazole shows scarce transdermal penetration. Flutrimazole has the advantageous in the research of topical fungal infections with an inflammatory component[1].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Fungal
References	[1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25. [2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

Description

Related Catalog

Research Areas >> Infection

Signaling Pathways >> Anti-infection >> Fungal

References

[1]. Merlos M, et al. Topical anti-inflammatory properties of flutrimazole, a new imidazole antifungal agent. Inflamm Res. 1996;45(1):20-25.

[2]. Ramis J, et al. Influence of formulation on the in vitro transdermal penetration of flutrimazole. Arzneimittelforschung. 1997;47(10):1139-1144.

Density	1.2±0.1 g/cm3
Boiling Point	457.1±40.0 °C at 760 mmHg
Melting Point	161-166ºC
Molecular Formula	C₂₂H₁₆F₂N₂
Molecular Weight	346.373
Flash Point	230.3±27.3 °C
Exact Mass	346.128143
PSA	17.82000
LogP	4.95
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.590

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NI6259450

CHEMICAL NAME :: 1H-Imidazole, 1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-

CAS REGISTRY NUMBER :: 119006-77-8

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H16-F2-N2

MOLECULAR WEIGHT :: 346.40

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 808 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1079 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 42,841,1992

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Precursor 5
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DownStream 0

Double-blind randomized dose-finding study in acute vulvovaginal candidosis. Comparison of flutrimazole site-release cream (1, 2 and 4%) with placebo site-release vaginal cream.

Mycoses 43(9-10) , 355-65, (2000)

A double-blind randomized comparative phase II study of flutrimazole site-release vaginal cream (1, 2 and 4%) with placebo site-release vaginal cream was undertaken in patients with acute vulvovaginal...

Efficacy of flutrimazole 1% powder in the treatment of tinea pedis.

Mycoses 46(3-4) , 126-31, (2003)

The aim of the study was to compare the efficacy and tolerability of flutrimazole 1% powder vs. bifonazole 1% powder in treating tinea pedis. A multicentre, double blind, randomized, parallel and comp...

Study to compare the efficacy and safety of fluconazole cream with flutrimazole cream in the treatment of superficial mycosis: a multicentre, randomised, double-blind, phase III trial.

Mycoses 53(6) , 522-9, (2010)

Fluconazole, which is a drug of the azole family, is safely used in systemic treatment of oral and intravenous injection, but it is difficult to use fluconazole as a topical application because of its...

Flutrimazolum

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-Imidazol

Flutrimazole (INN)

FLUTRIMAZOLE

1-((2-fluorophenyl)(4-fluorophenyl)phenylmethyl)-1H-imidazole

Micetal

Flutrimazolum [INN-Latin]

Flutrimazol [INN-Spanish]

1-[(2-fluorophenyl)-(4-fluorophenyl)-phenylmethyl]imidazole

MFCD00865591

Flutrimazol

1-[(2-Fluorophenyl)(4-fluorophenyl)phenylmethyl]-1H-imidazole

1-[o-Fluoro-a-(p-fluorophenyl)-a-phenylbenzyl]imidazole

1H-Imidazole, 1-[(2-fluorophenyl)(4-fluorophenyl)phenylmethyl]-

UR-4056

Shanghai Jizhi Biochemical Technology Co., Ltd
China
Product Name: FLUTRIMAZOLE
Price: ￥1788.0/250mg ￥4288.0/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Liu jia

DC Chemicals Limited
China
Product Name: Flutrimazole
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Flutrimazole
Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
Purity: 98.0%
Stocking Period: Inquiry
Contact: Ms Wang

Henan Tianfu Chemical Co., Ltd.
China
Product Name: Flutrimazole
Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
Purity: 99.0%
Stocking Period: Inquiry
Contact: Anson

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