3,3'-Disulfanediyldipropanoic acid

Modify Date: 2024-01-02 12:41:20

3,3'-Disulfanediyldipropanoic acid Structure
3,3'-Disulfanediyldipropanoic acid structure
Common Name 3,3'-Disulfanediyldipropanoic acid
CAS Number 1119-62-6 Molecular Weight 210.271
Density 1.5±0.1 g/cm3 Boiling Point 431.1±30.0 °C at 760 mmHg
Molecular Formula C6H10O4S2 Melting Point 155-158 °C(lit.)
MSDS Chinese USA Flash Point 214.5±24.6 °C
Symbol GHS07
GHS07
Signal Word Warning

 Use of 3,3'-Disulfanediyldipropanoic acid


Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].

 Names

Name 3,3′-Dithiodipropionic acid
Synonym More Synonyms

 3,3'-Disulfanediyldipropanoic acid Biological Activity

Description Dithiodipropionic acid can interact with CPUL1 (HY-151802, a TrxR inhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundant ROS to induce cell apoptosis than that of free CPUL1, and improves antitumor efficacy against HUH7 cancer cells[1].
Related Catalog
In Vitro CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50 value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1]. CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1]. CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1].
References

[1]. Jing Liu, et al. Nanoaggregates of Disulfide-Decorated TrxR Inhibitor Promote Cellular Uptake, Selective Targeting, and Antitumor Efficacy. Langmuir.

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Boiling Point 431.1±30.0 °C at 760 mmHg
Melting Point 155-158 °C(lit.)
Molecular Formula C6H10O4S2
Molecular Weight 210.271
Flash Point 214.5±24.6 °C
Exact Mass 210.002045
PSA 125.20000
LogP 1.38
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.592

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Personal Protective Equipment dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes C:Corrosive;
Risk Phrases R34
Safety Phrases S26-S36
RIDADR 1759
WGK Germany 3
Packaging Group III
Hazard Class 8
HS Code 2930909090

 Synthetic Route

 Customs

HS Code 2930909090
Summary 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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 Synonyms

MFCD00002780
3-(2-carboxyethyldisulfanyl)propanoic acid
Propanoic acid, 3,3'-dithiobis-
3,3'-Dithiodipropionic acid
3,3'-Disulfanediyldipropanoic acid
EINECS 214-284-0
3,3-Dithiodipropionic Acid
3,3‘-Dithiodipropionic acid
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