Ginkgolide J

Modify Date: 2024-01-02 12:05:11

Ginkgolide J Structure
Ginkgolide J structure
Common Name Ginkgolide J
CAS Number 107438-79-9 Molecular Weight 424.399
Density 1.6±0.1 g/cm3 Boiling Point 760.4±60.0 °C at 760 mmHg
Molecular Formula C20H24O10 Melting Point 41-42 °C
MSDS USA Flash Point 273.6±26.4 °C

 Use of Ginkgolide J


Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability[1][2].

 Names

Name Ginkgolide J
Synonym More Synonyms

 Ginkgolide J Biological Activity

Description Ginkgolide J is a main constituent of the non-flavone fraction of Ginkgo biloba with an IC50 range of 12-54 µM, has neuroprotective and anti neuronal apoptotic ability[1][2].
Related Catalog
In Vivo Ginkgolide J (100 μM) treatment reduces the apoptotic damage induced by serum deprivation (24h) or treatment with Staurosporine (200 nM, 24h) in cultured chick embryonic neurons[1].
References

[1]. Ahlemeyer B, et al. Pharmacological studies supporting the therapeutic use of Ginkgo biloba extract for Alzheimer's disease. Pharmacopsychiatry. 2003 Jun; 36 Suppl 1:S8-14.

[2]. Sylvia Pietri, et al. Synthesis and Biological Studies of a New Ginkgolide C Derivative: Evidence That the Cardioprotective Effect of Ginkgolides Is Unrelated to PAF Inhibition. DRUG DEVELOPMENT RESEARCH. 2001.54:191-201.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 760.4±60.0 °C at 760 mmHg
Melting Point 41-42 °C
Molecular Formula C20H24O10
Molecular Weight 424.399
Flash Point 273.6±26.4 °C
Exact Mass 424.136932
PSA 148.82000
LogP -0.68
Vapour Pressure 0.0±5.8 mmHg at 25°C
Index of Refraction 1.651

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
RIDADR NONH for all modes of transport
WGK Germany 3.0

 Articles11

More Articles
Complete 1H NMR spectral analysis of ten chemical markers of Ginkgo biloba.

Magn. Reson. Chem. 50(8) , 569-75, (2012)

The complete and unambiguous (1)H NMR assignments of ten marker constituents of Ginkgo biloba are described. The comprehensive (1)H NMR profiles (fingerprints) of ginkgolide A, ginkgolide B, ginkgolid...

Rapid analysis of terpene lactones in extract of Ginkgo biloba L. by high performance liquid chromatography.

Se Pu 18(5) , 394-7, (2000)

A new rapid analytical method was developed for the quantification of terpene lactones (bilobalide(BB) and ginkgolide A, B, C, J) in extract of Ginkgo biloba L. (EGb) using a liquid-liquid solvent ext...

Protection against beta-amyloid induced abnormal synaptic function and cell death by Ginkgolide J.

Neurobiol. Aging 30(2) , 257-65, (2009)

A new Ginkgo biloba extract P8A (TTL), 70% enriched with terpene trilactones, prevents A beta(1-42) induced inhibition of long-term potentiation in the CA1 region of mouse hippocampal slices. This neu...

 Synonyms

6H-9,4a-(Epoxymethano)-3aH,9H-cyclopenta[c]furo[2,3-b]furo[3',2':3,4]cyclopenta[1,2-d]furan-2,6,13(1H)-trione, 11-(1,1-dimethylethyl)hexahydro-1,4b,10-trihydroxy-5-methyl-, (1R,3aR,4aR,4bR,5S,7aS,8aS,9S,10R,11S,11aS)-
(1R,3R,6R,7S,8S,9R,10S,11S,13S,16S,17R)-6,9,17-Trihydroxy-16-methyl-8-(2-methyl-2-propanyl)-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione
GinkgolideJ
(1R,3R,6R,7S,8S,9R,10S,11S,13S,16S,17R)-8-tert-Butyl-6,9,17-trihydroxy-16-methyl-2,4,14,19-tetraoxahexacyclo[8.7.2.0.0.0.0]nonadecane-5,15,18-trione
Ginkgolid J
7beta-hydroxyginkgolide a
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