AZD8329
Modify Date: 2024-01-13 15:51:55
AZD8329 structure
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Common Name | AZD8329 | ||
|---|---|---|---|---|
| CAS Number | 1048668-70-7 | Molecular Weight | 421.53200 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C25H31N3O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of AZD8329AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1]. |
| Name | 4-[4-(1-adamantylcarbamoyl)-5-tert-butylpyrazol-1-yl]benzoic acid |
|---|---|
| Synonym | More Synonyms |
| Description | AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1]. |
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| Related Catalog | |
| Target |
IC50: 9 nM (Human 11β-HSD1)[1] |
| In Vitro | AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively[1]. |
| References |
| Molecular Formula | C25H31N3O3 |
|---|---|
| Molecular Weight | 421.53200 |
| Exact Mass | 421.23700 |
| PSA | 87.71000 |
| LogP | 5.14140 |
|
~89%
AZD8329 CAS#:1048668-70-7 |
| Literature: Scott, James S.; Deschoolmeester, Joanne; Kilgour, Elaine; Mayers, Rachel M.; Packer, Martin J.; Hargreaves, David; Gerhardt, Stefan; Ogg, Derek J.; Rees, Amanda; Selmi, Nidhal; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10136 - 10147 |
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~%
AZD8329 CAS#:1048668-70-7 |
| Literature: Scott, James S.; Deschoolmeester, Joanne; Kilgour, Elaine; Mayers, Rachel M.; Packer, Martin J.; Hargreaves, David; Gerhardt, Stefan; Ogg, Derek J.; Rees, Amanda; Selmi, Nidhal; Stocker, Andrew; Swales, John G.; Whittamore, Paul R.O. Journal of Medicinal Chemistry, 2012 , vol. 55, # 22 p. 10136 - 10147 |
![methyl 4-[4-(2-Adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoate structure](https://www.chemsrc.com/caspic/377/1048668-71-8.png)
| Precursor 2 | |
|---|---|
| DownStream 0 | |
| unii-5b38cv1212 |