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AZD8329

Names

[ CAS No. ]:
1048668-70-7

[ Name ]:
AZD8329

[Synonym ]:
unii-5b38cv1212

Biological Activity

[Description]:

AZD8329 is a potent 11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with an IC50 of 9 nM for human 11β-HSD1, displays excellent selectivity versus 11β-HSD2, 17β-HSD1 and 17β-HSD3[1].

[Related Catalog]:

Signaling Pathways >> Others >> Others
Research Areas >> Metabolic Disease

[Target]

IC50: 9 nM (Human 11β-HSD1)[1]


[In Vitro]

AZD8329 shows IC50s of 0.009, 0.0086, 0.008, 0.024, 0.002 and 6.1 μM for human enzyme, rat enzyme, dog enzyme, cyno enzyme, human adipocyte and mouse enzyme, respectively[1].

[References]

[1]. Scott JS, et al. Novel acidic 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) inhibitor with reduced acyl glucuronide liability: the discovery of 4-[4-(2-adamantylcarbamoyl)-5-tert-butyl-pyrazol-1-yl]benzoic acid (AZD8329). J Med Chem. 2012 Nov 26;55(22):10136-47.

Chemical & Physical Properties

[ Molecular Formula ]:
C25H31N3O3

[ Molecular Weight ]:
421.53200

[ Exact Mass ]:
421.23700

[ PSA ]:
87.71000

[ LogP ]:
5.14140

Synthetic Route

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Precursor & DownStream

Precursor

DownStream

Related Compounds