- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: 4-Diethylaminobenzaldehyde
- Price: ￥808.0/500g ￥128.0/100g
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 4-Diethylaminobenzaldehyde
- Price:
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Dayang Chem (Hangzhou) Co., Ltd.
- China
- Product Name: 4-Diethylaminobenzaldehyde
- Price: $Inquiry/100g $Inquiry/1kg $Inquiry/100kg $Inquiry/1000kg
- Purity: 98.0%
- Stocking Period: Inquiry
- Contact: Ms Wang
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: 4-(N,N-diethylamino)benzaldehyde
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
120-21-8
120-21-8 structure
- Name: 4-Diethylaminobenzaldehyde
- Chemical Name: 4-(diethylamino)benzaldehyde
- CAS Number: 120-21-8
- Molecular Formula: C11H15NO
- Molecular Weight: 177.243
- Catalog: Signaling Pathways Metabolic Enzyme/Protease Aldehyde Dehydrogenase (ALDH)
- Create Date: 2018-09-20 17:59:43
- Modify Date: 2024-01-02 08:49:02
-
4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2].
| Name | 4-(diethylamino)benzaldehyde |
|---|---|
| Synonyms |
Benzaldehyde, 4-(diethylamino)-
MFCD00003382 4-Diethylaminobenzaldehyde 4-Diethylaminobenzoaldehyde 4-(Diethylamino)benzaldehyde EINECS 204-377-4 p-(Diethylamino)benzaldehyde 4-(Diethylamino)-Benzaldehyde Benzaldehyde, p-(diethylamino)- |
| Description | 4-Diethylaminobenzaldehyde is a reversible aldehyde dehydrogenases (ALDHs) inhibitor, with a Ki of 4 nM for ALDH1. 4-Diethylaminobenzaldehyde displays potent anti-androgenic effect (IC50= 1.71μM)[1][2]. |
|---|---|
| Related Catalog | |
| In Vitro | 4-Diethylaminobenzaldehyde (DEAB) is reversible competitive inhibitor of ALDH1 (competitive with the aldehyde substrate) with a Ki value of 4 nM, and irreversibly inactivates ALDH7A1 via formation of a stable, covalent acyl-enzyme species[1]. The Temozolomide (TMZ)-resistant cell line LN18 is treated with a combination of TMZ and 4-Diethylaminobenzaldehyde for 10 days. As indicated by colony formation assay, the clonogenic capacity of LN18 cells exposed to TMZ in combination with 4-Diethylaminobenzaldehyde (DEAB) is significantly attenuated[3]. |
| References |
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 329.6±0.0 °C at 760 mmHg |
| Melting Point | 37-41 °C(lit.) |
| Molecular Formula | C11H15NO |
| Molecular Weight | 177.243 |
| Flash Point | 110.2±12.0 °C |
| Exact Mass | 177.115356 |
| PSA | 20.31000 |
| LogP | 2.87 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.571 |
| Water Solubility | insoluble |
| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H312-H315-H319-H335 |
| Precautionary Statements | P280-P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
| Hazard Codes | Xn:Harmful;N:Dangerousfortheenvironment; |
| Risk Phrases | R21/22;R50/53 |
| Safety Phrases | S26-S36-S61-S60-S36/37 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | CU5612850 |
| HS Code | 2922399090 |
| Precursor 10 | |
|---|---|
| DownStream 10 | |
![N-[4-(diethylamino)benzylidene]-4-(dimethylamino)aniline structure](https://www.chemsrc.com/caspic/010/82529-61-1.png)
![methyl 2-cyano-3-[4-(diethylamino)phenyl]prop-2-enoate structure](https://www.chemsrc.com/caspic/190/100957-69-5.png)
![5-[(4-dimethylaminophenyl)methylidene]imidazolidine-2,4-dione structure](https://www.chemsrc.com/caspic/448/10040-87-6.png)
| HS Code | 2922399090 |
|---|---|
| Summary | 2922399090 other amino-aldehydes, amino-ketones and amino-quinones, other than those containing more than one kind of oxygen function; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0% |