146510-36-3
146510-36-3 structure
- Name: Olanexidine
- Chemical Name: 1-carbamimidoyl-2-[(3,4-dichlorophenyl)methyl]-1-octylguanidine
- CAS Number: 146510-36-3
- Molecular Formula: C17H27Cl2N5
- Molecular Weight: 372.33600
- Catalog: Signaling Pathways Anti-infection Bacterial
- Create Date: 2018-07-22 18:35:41
- Modify Date: 2024-01-04 22:59:40
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Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3].
| Name | 1-carbamimidoyl-2-[(3,4-dichlorophenyl)methyl]-1-octylguanidine |
|---|---|
| Synonyms |
Olanexidine
N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide Imidodicarbonimidicdiamide,N-[(3,4-dichlorophenyl)methyl]-N'-octyl |
| Description | Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3]. |
|---|---|
| Related Catalog | |
| In Vitro | Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria[1]. Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells[2]. Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles[3]. Cell Viability Assay[1] Cell Line: Gram-positive cocci, Enterococcus spp., Gram-positive bacilli, Gram-negative strains Concentration: 0-1 mg/mL approximately Incubation Time: 30 s Result: Inhibited bacterial activity with MIC values ranging from 6.8 to 1740 μg/mL approximately. |
| In Vivo | Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys[4]. Animal Model: Male cynomolgus monkeys[4] Dosage: 1 %, 1.5%, 2% in saline Administration: Applied to the skin Result: Showed the fast-acting and long-lasting bactericidal effects at 1.5% concentration. |
| Density | 1.22g/cm3 |
|---|---|
| Boiling Point | 503.3ºC at 760 mmHg |
| Molecular Formula | C17H27Cl2N5 |
| Molecular Weight | 372.33600 |
| Flash Point | 258.2ºC |
| Exact Mass | 371.16400 |
| PSA | 83.79000 |
| LogP | 5.86440 |
| Vapour Pressure | 2.96E-10mmHg at 25°C |
| Index of Refraction | 1.576 |