Dayang Chem (Hangzhou) Co., Ltd.
China
Product Name: Gentamicin C1a
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Purity: 98.0%
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26098-04-4

26098-04-4 structure

26098-04-4 structure

Name: gentamycin C1a
Chemical Name: gentamycin C1a
CAS Number: 26098-04-4
Molecular Formula: C₁₉H₃₉N₅O₇
Molecular Weight: 449.54200
Catalog: Signaling Pathways Anti-infection Bacterial
Create Date: 2018-09-06 09:03:21
Modify Date: 2024-01-02 22:41:19
Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].

Name	gentamycin C1a
Synonyms	Geneticin C1a Gentamicin C1a Pentaacetate Salt GentaMycin C1a Acetate Gentamycin C1a GentaMicin C3 Acetate Gentamisin C3 Gentamicin D Gentamicin C1a GentaMicin D Acetate Gentamicin C3

Description	Gentamicin C1a is the precursor of the semi-synthetic antibiotic Etimicin, and has antibacterial activity. Gentamicin C1a is the major component of the Gentamicin complex[1][2].
Related Catalog	Research Areas >> Infection Signaling Pathways >> Anti-infection >> Bacterial
In Vitro	Gentamicin C1a 抑制 Escherichia coli,P. aeruginosa 和 S. aureus 活性，IC50 值为 1 mg/mL[2]。 Gentamicin C1a (2 mM, 48 h) 对 OC-k3 细胞活力没有影响[2].
In Vivo	Gentamicin C1a (4 mg/kg，静脉推注剂量，单次) 在比格犬体内的平均停留时间为 84 分钟，CL 值为 1.81 mL/min/kg[3]。
References	[1]. Li D, et al. Construction of a gentamicin C1a-overproducing strain of Micromonospora purpurea by inactivation of the gacD gene. Microbiol Res. 2013 Jun 12;168(5):263-7. [2]. Ishikawa M, et al. Lower ototoxicity and absence of hidden hearing loss point to gentamicin C1a and apramycin as promising antibiotics for clinical use. Sci Rep. 2019 Feb 20;9(1):2410. [3]. Isoherranen N, et al. Pharmacokinetics of gentamicin C(1), C(1a), and C(2) in beagles after a single intravenous dose. Antimicrob Agents Chemother. 2000 Jun;44(6):1443-7.

Density	1.36g/cm3
Boiling Point	675.2ºC at 760 mmHg
Melting Point	102-108ºC
Molecular Formula	C₁₉H₃₉N₅O₇
Molecular Weight	449.54200
Flash Point	362.1ºC
Exact Mass	449.28500
PSA	213.72000
Vapour Pressure	3.97E-21mmHg at 25°C
Index of Refraction	1.603

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WK2290000

CHEMICAL NAME :: D-Streptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopy ranosyl-(1-6)-O-(2,6- diamino-2,3,4,6-tetradeoxy-alpha-D-erythro-hexopyrano syl-(1-4))-2-deoxy-

CAS REGISTRY NUMBER :: 26098-04-4

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H39-N5-O7

MOLECULAR WEIGHT :: 449.63

WISWESSER LINE NOTATION :: T6OTJ CQ DM1 EQ E1 BO- BL6TJ AZ CQ EZ DO- BT6OTJ CZ F1Z

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 38KLAC "Structure-Activity Relationship among the Semisynthetic Antibiotics," Perlman, D., ed., New York, Academic Press, 1977 Volume(issue)/page/year: -,239,1977

Hazard Codes	Xn
HS Code	3004909090

32385-11-8 structure

32385-11-8

~%

26098-04-4 structure

26098-04-4

52093-21-7 structure

52093-21-7

Literature: Agricultural and Biological Chemistry, , vol. 46, # 2 p. 515 - 522

Precursor 1
32385-11-8
DownStream 0

HS Code	3004909090