DC Chemicals Limited
China
Product Name: NOS-IN-1
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Purity: 98.0%
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Contact: Tony Cao

165383-72-2

165383-72-2 structure

165383-72-2 structure

Name: NOS-IN-1
Chemical Name: 2-Imino-4-methylpiperidine, Acetate
CAS Number: 165383-72-2
Molecular Formula: C₈H₁₆N₂O₂
Molecular Weight: 172.225
Catalog: Signaling Pathways Immunology/Inflammation NO Synthase
Create Date: 2018-12-02 22:37:59
Modify Date: 2024-02-02 21:29:24
NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively[1].

Name	2-Imino-4-methylpiperidine, Acetate
Synonyms	2-Pyridinamine, 3,4,5,6-tetrahydro-4-methyl-, acetate (1:1) 4-Methylpiperidin-2-imine acetate (1:1) acetic acid,4-methyl-2,3,4,5-tetrahydropyridin-6-amine 4-Methyl-3,4,5,6-tetrahydro-2-pyridinamine acetate (1:1) 2-Piperidinimine, 4-methyl-, acetate (1:1)

Description	NOS-IN-1 is a potent and orally active NO synthase (NOS) isoforms inhibitor with IC50s of 0.1 μM, 1.1 μM, and 0.2 μM for human iNOS (hiNOS), heNOS and hnNOS, respectively[1].
Related Catalog	Signaling Pathways >> Immunology/Inflammation >> NO Synthase Research Areas >> Inflammation/Immunology
Target	IC50: 0.1 μM (hiNOS), 1.1 μM (heNOS), and 0.2 μM (hnNOS)[1]
In Vivo	Following oral administration, NOS-IN-1 (compound 3; 10 mg/kg) decreases serum nitrite/nitrate levels in an in vivo rat endotoxin assay[1].
References	[1]. R K Webber, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101.

Melting Point	181-182ºC
Molecular Formula	C₈H₁₆N₂O₂
Molecular Weight	172.225
Exact Mass	172.121185
PSA	73.18000
LogP	1.50260

HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%