CHEMICAL IDENTIFICATION
-
RTECS NUMBER :
-
BP4550000
-
CHEMICAL NAME :
-
Ammonium chloride
-
CAS REGISTRY NUMBER :
-
12125-02-9
-
LAST UPDATED :
-
199806
-
DATA ITEMS CITED :
-
38
-
MOLECULAR FORMULA :
-
Cl-H4-N
-
MOLECULAR WEIGHT :
-
53.50
-
WISWESSER LINE NOTATION :
-
Z& G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
Standard Draize test
-
ROUTE OF EXPOSURE :
-
Administration into the eye
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Human - infant
-
DOSE/DURATION :
-
2 gm/kg
-
TOXIC EFFECTS :
-
Cardiac - other changes
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
1650 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intramuscular
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
30 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
1300 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intraperitoneal
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
485 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
500 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LD50 - Lethal dose, 50 percent kill
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - mouse
-
DOSE/DURATION :
-
358 mg/kg
-
TOXIC EFFECTS :
-
Behavioral - convulsions or effect on seizure threshold Behavioral - coma Lungs, Thorax, or Respiration - respiratory stimulation
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - dog
-
DOSE/DURATION :
-
600 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
1 gm/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
200 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - rabbit
-
DOSE/DURATION :
-
78 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Subcutaneous
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
72 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Intravenous
-
SPECIES OBSERVED :
-
Rodent - guinea pig
-
DOSE/DURATION :
-
220 mg/kg
-
TOXIC EFFECTS :
-
Details of toxic effects not reported other than lethal dose value
-
TYPE OF TEST :
-
LDLo - Lowest published lethal dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Mammal - domestic
-
DOSE/DURATION :
-
1500 mg/kg
-
TOXIC EFFECTS :
-
Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - tremor Lungs, Thorax, or Respiration - respiratory stimulation
-
TYPE OF TEST :
-
TDLo - Lowest published toxic dose
-
ROUTE OF EXPOSURE :
-
Oral
-
SPECIES OBSERVED :
-
Rodent - rat
-
DOSE/DURATION :
-
51660 mg/kg/10W-C
-
TOXIC EFFECTS :
-
Kidney, Ureter, Bladder - other changes in urine composition Nutritional and Gross Metabolic - changes in calcium
MUTATION DATA
-
TYPE OF TEST :
-
Cytogenetic analysis
-
TEST SYSTEM :
-
Rodent - hamster Fibroblast
-
REFERENCE :
-
FCTOD7 Food and Chemical Toxicology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.20- 1982- Volume(issue)/page/year: 22,623,1984 *** REVIEWS *** ACGIH TLV-STEL 20 mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 10 mg/m3, fume DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** U.S. STANDARDS AND REGULATIONS *** MSHA STANDARD-air:TWA 10 mg/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,12,1971 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 10 mg/m3 (fume) JAN 1993 OEL-AUSTRALIA:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL-BELGIUM:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL-DENMARK:TWA 10 mg/m3 (fume) JAN 1993 OEL-FRANCE:TWA 10 mg/m3 (fume) JAN 1993 OEL-THE NETHERLANDS:TWA 10 mg/m3 (fume) JAN 1993 OEL-RUSSIA:STEL 10 mg/m3 (fume) JAN 1993 OEL-SWITZERLAND:TWA 6 mg/m3 (fume) JAN 1993 OEL-UNITED KINGDOM:TWA 10 mg/m3;STEL 20 mg/m3 (fume) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO AMMONIUM CHLORIDE-air:10H TWA 10 mg/m3;STEL 20 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 05270 No. of Facilities: 29596 (estimated) No. of Industries: 223 No. of Occupations: 97 No. of Employees: 259567 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 05270 No. of Facilities: 24833 (estimated) No. of Industries: 180 No. of Occupations: 131 No. of Employees: 415676 (estimated) No. of Female Employees: 139037 (estimated)
|