58569-55-4

58569-55-4 structure

Name: Met-Enkephalin acetate salt
Chemical Name: 2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
CAS Number: 58569-55-4
Molecular Formula: C₂₇H₃₅N₅O₇S
Molecular Weight: 573.66100
Catalog: Biochemical Peptide
Create Date: 2018-05-17 08:00:00
Modify Date: 2024-01-02 17:21:26
Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.

Name	2-[[2-[[2-[[2-[[2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylsulfanylbutanoic acid
Synonyms	MET-enkephalin ENKEPHALIN,METHIONINE 1-5-Adrenorphin (human) H-Tyr(1)-Gly(2)-Gly(3)-Phe(4)-Met(5)-OH Methionine enkephalin [Met5]-enkephalin TYR-GLY-GLY-PHE-MET Opioid growth factor H-Tyr-Gly-Gly-Phe-Met-OH EINECS 261-335-8 Tyr-Gly-Gly-Phe-Met-OH Lupex

Description	Tyr-Gly-Gly-Phe-Met-OH regulates human immune function and inhibits tumor growth via binding to the opioid receptor.
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Opioid Receptor Signaling Pathways >> Neuronal Signaling >> Opioid Receptor Research Areas >> Neurological Disease Peptides
Target	Opioid Receptor[1].
In Vitro	Methionine enkephalin (MENK), an endogenous neuropeptide has a crucial role in both neuroendocrine and immune systems. MENK is believed to have an immunoregulatory activity to have cancer biotherapy activity by binding to the opioid receptors on immune and cancer cells. MENK may also change the tumor microenvironment by binding to opioid receptor on or in cancer cells. All of these mechanisms of action have biologic significance and potential for use in cancer immunotherapy. Furthermore, they reveal a relationship between the endocrine and immune systems[1].
References	[1]. Zhao D, et al. Methionine enkephalin, its role in immunoregulation and cancer therapy. Int Immunopharmacol. 2016 Feb 23. pii: S1567-5769(16)30050-9.

Safety Phrases	S22-S24/25
WGK Germany	3