Name | Cyclosporin D |
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Synonyms |
33-[(4E)-1-Hydroxy-2-methylhex-4-en-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone
33-[(4E)-1-hydroxy-2-methylhex-4-en-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-6,9,18,24-tetrakis(2-methylpropyl)-3,21,30-tri(propan-2-yl)-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone CyclosporinD cyclosporine D Val2-Cyclosporine 1,4,7,10,13,16,19,22,25,28,31-Undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone, 33-[(4E)-1-hydroxy-2-methyl-4-hexen-1-yl]-1,4,7,10,12,15,19,25,28-nonamethyl-3,21,30-tris(1-methylethyl)-6,9,18,24-tetrakis(2-methylpropyl)- 33-[(4E)-1-Hydroxy-2-methyl-4-hexen-1-yl]-6,9,18,24-tetraisobutyl-3,21,30-triisopropyl-1,4,7,10,12,15,19,25,28-nonamethyl-1,4,7,10,13,16,19,22,25,28,31-undecaazacyclotritriacontane-2,5,8,11,14,17,20,23,26,29,32-undecone 7-L-Valinecyclosporin A Cyclosporin Impurity 4 |
Description | Cyclosporin D, a metabolite of Cyclosporin A, is a weak immunosuppressant. Cyclosporin D is used as internal standard for quantification of Cyclosporin A[1][2]. Cyclosporin A is a potent immunosuppressant drug, suppress T cell activation by inhibiting calcineurin and the calcineurin-dependent transcription factors nuclear factor of activated T cells (NFAc)[3]. |
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Related Catalog | |
In Vitro | Cyclosporine D inhibits Ca2+/calmodulin dependent EF-2 phosphorylation in vitro[1]. |
In Vivo | Cyclosporine D is a potent inhibitor in vivo of phorbol ester TPA-induced biological effects in mouse skin[1]. |
References |
Density | 1.0±0.1 g/cm3 |
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Boiling Point | 1294.7±65.0 °C at 760 mmHg |
Melting Point | 148-151ºC |
Molecular Formula | C63H113N11O12 |
Molecular Weight | 1216.638 |
Flash Point | 736.8±34.3 °C |
Exact Mass | 1215.857056 |
PSA | 275.64000 |
LogP | 3.70 |
Vapour Pressure | 0.0±0.6 mmHg at 25°C |
Index of Refraction | 1.468 |
Storage condition | 20°C |
Symbol |
GHS02, GHS07 |
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Signal Word | Danger |
Hazard Statements | H225-H302 + H312 + H332-H319 |
Precautionary Statements | P210-P280-P305 + P351 + P338 |
Hazard Codes | F,Xn,T |
Risk Phrases | 11-20/21/22-36-39/23/24/25-23/24/25 |
Safety Phrases | 16-36/37-45-7 |
RIDADR | UN 1648 3 / PGII |
HS Code | 29419090 |