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Related CAS#:
81-64-1 103220-12-8
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81-64-1

81-64-1 structure
81-64-1 structure
  • Name: Quinizarin
  • Chemical Name: quinizarin
  • CAS Number: 81-64-1
  • Molecular Formula: C14H8O4
  • Molecular Weight: 240.211
  • Catalog: Organic raw materials Terpenoid
  • Create Date: 2018-09-24 10:16:30
  • Modify Date: 2024-01-03 11:16:09
  • Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].
Name quinizarin
Synonyms MFCD00001209
EINECS 201-368-7
1,4-hydroxyanthraquinone
QUINIZARINE
DSD ACID
smokeoranger
1,4-Dihydroxy-9,10-anthraquinone
Quinizarin
Chinizarin
1,4-Dihydroxy-9,10-anthracene-dione
1,4-Dihydroxyanthraquinone
9,10-Anthracenedione, 1,4-dihydroxy-
Quinizalin
QUINAZARIN
1,4-Doa
1,4-dihydroxyanthracene-9,10-dione
quiniazarine
Description Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2].
Related Catalog
In Vitro 1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu(2+) in aqueous solution[1].
References

[1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55.

[2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin.

[3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373.
Density 1.5±0.1 g/cm3
Boiling Point 465.3±40.0 °C at 760 mmHg
Melting Point 198-199 °C(lit.)
Molecular Formula C14H8O4
Molecular Weight 240.211
Flash Point 249.3±23.8 °C
Exact Mass 240.042252
PSA 74.60000
LogP 4.47
Vapour density 8.3 (vs air)
Vapour Pressure 0.0±1.2 mmHg at 25°C
Index of Refraction 1.733
Water Solubility <1 g/L (20 ºC)

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CB6600000
CHEMICAL NAME :
Anthraquinone, 1,4-dihydroxy-
CAS REGISTRY NUMBER :
81-64-1
LAST UPDATED :
199701
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C14-H8-O4
MOLECULAR WEIGHT :
240.22
WISWESSER LINE NOTATION :
L C666 BV IVJ DQ GQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>5 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>10 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82067 No. of Facilities: 563 (estimated) No. of Industries: 10 No. of Occupations: 9 No. of Employees: 6634 (estimated)
Symbol GHS09
GHS09
Signal Word Warning
Hazard Statements H410
Precautionary Statements P273-P501
Personal Protective Equipment Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes Xi
Risk Phrases R36/37/38
Safety Phrases S22-S24/25
RIDADR UN 3077 9 / PGIII
WGK Germany 2
RTECS CB6600000
Packaging Group II; III
Hazard Class 4.1
HS Code 2914610000
HS Code 2914610000
Summary 2914610000 anthracene-9,10-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0%

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title: CAS No. 81-64-1 | Chemsrc address: https://www.chemsrc.com/en/baike/888368.html

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