Name | Glycoursodeoxycholic acid |
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Synonyms | Glycoursodeoxycholic Acid |
Description | Glycoursodeoxycholic acid, a acyl glycine and a bile acid-glycine conjugate, is a metabolite of ursodeoxycholic acid.In Vitro: The antioxidant compound glycoursodeoxycholic acid (GUDCA) fully abrogates UCB-induced cytochrome c oxidase inhibition and significantly prevents oxidative stress, metabolic alterations, and cell demise[1].GUDCA has shown therapeutic efficacy in neurodegenerative models and diseases. Increased cytosolic SOD1 inclusions were observed in 4 DIV NSC-34/hSOD1(G93A) cells together with decreased mitochondria viability, caspase-9 activation, and apoptosis[2]. Glycoursodeoxycholic acid shows preventive and restorative effects against unconjugated bilirubin -induced blood-brain barrier disruption and damage to human brain microvascular endothelial cells[3]. |
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Related Catalog |
Melting Point | 232-235ºC |
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Molecular Formula | C26H43NO5 |
Molecular Weight | 449.62300 |
Exact Mass | 449.31400 |
PSA | 106.86000 |
LogP | 3.98500 |
Storage condition | -20°C Freezer |
RIDADR | NONH for all modes of transport |
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