68506-86-5
68506-86-5 structure
- Name: Vigabatrin
- Chemical Name: Vigabatrin
- CAS Number: 68506-86-5
- Molecular Formula: C6H11NO2
- Molecular Weight: 129.157
- Catalog: Signaling Pathways Membrane Transporter/Ion Channel GABA Receptor
- Create Date: 2018-04-26 08:00:00
- Modify Date: 2024-01-02 19:46:25
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Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.IC50 value:Target: GABA transaminaseClinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 μg) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment.
| Name | Vigabatrin |
|---|---|
| Synonyms |
UNII:GR120KRT6K
vigabatrinum [INN_la] (±)-γ-Vinyl-GABA vigabatrine Vigabatrin vigabatrinum 4-Aminohex-5-enoic acid Sabril vigabatrina 4-Amino-5-hexenoic acid 5-Hexenoic acid, 4-amino- |
| Description | Vigabatrin(γ-Vinyl-GABA; Sabril) is a structural analog of the inhibitory neurotransmitter γ-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.IC50 value:Target: GABA transaminaseClinical studies have shown that vigabatrin is superior to placebo in decreasing the frequency of infantile spasms. In tuberous sclerosis, vigabatrin may be considered the first-line treatment for IS. The mode of action is increasing concentrations of the inhibitory neurotransmitter GABA in the brain.A significant increase in seizure threshold was observed following systemic (i.p.) administration of high (600 or 1200 mg/kg) doses of vigabatrin. Bilateral microinjection of vigabatrin (10 μg) into either the anterior or posterior SNr also increased seizure threshold, but less markedly than systemic treatment. |
|---|---|
| Related Catalog | |
| References |
[4]. Vigabatrin |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 277.7±28.0 °C at 760 mmHg |
| Molecular Formula | C6H11NO2 |
| Molecular Weight | 129.157 |
| Flash Point | 121.7±24.0 °C |
| Exact Mass | 129.078979 |
| PSA | 63.32000 |
| LogP | -0.10 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.483 |
| Storage condition | 2-8℃ |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
|---|---|
| RIDADR | NONH for all modes of transport |
| RTECS | MP7745000 |